Literature DB >> 24270219

Guanidine bridged nucleic acid (GuNA): an effect of a cationic bridged nucleic acid on DNA binding affinity.

Ajaya R Shrestha1, Yutaro Kotobuki, Yoshiyuki Hari, Satoshi Obika.   

Abstract

A novel 2',4'-BNA/LNA analog bridged by guanidine, termed as guanidine bridged nucleic acid (GuNA), was synthesized and incorporated into oligonucleotides. Thermal stabilities and nuclease resistance of GuNA-modified oligonucleotides were investigated and compared with those of 2',4'-BNA/LNA and natural DNA oligonucleotides. GuNA exhibited interestingly high binding affinity towards complementary ssDNA than 2',4'-BNA/LNA.

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Year:  2013        PMID： 24270219     DOI： 10.1039/c3cc46017g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Synthesis of siRNAs incorporated with cationic peptides R8G7 and R8A7 and the effect of the modifications on siRNA properties.

Authors:  Miho Matsubara; Kenji Honda; Koki Ozaki; Ryohei Kajino; Yuri Kakisawa; Yusuke Maeda; Yoshihito Ueno
Journal:  RSC Adv       Date:  2020-09-21       Impact factor: 4.036

2.  Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold.

Authors:  Hibiki Komine; Shohei Mori; Kunihiko Morihiro; Kenta Ishida; Takumi Okuda; Yuuya Kasahara; Hiroshi Aoyama; Takao Yamaguchi; Satoshi Obika
Journal:  Molecules       Date:  2020-04-09       Impact factor: 4.411

3.  Design and In Vitro Evaluation of Splice-Switching Oligonucleotides Bearing Locked Nucleic Acids, Amido-Bridged Nucleic Acids, and Guanidine-Bridged Nucleic Acids.

Authors:  Takenori Shimo; Yusuke Nakatsuji; Keisuke Tachibana; Satoshi Obika
Journal:  Int J Mol Sci       Date:  2021-03-29       Impact factor: 5.923
  3 in total

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