Hakan Erdem1, Asuman Inan2, Selma Altındis3, Biljana Carevic4, Mehrdad Askarian5, Lucy Cottle6, Bojana Beovic7, Akos Csomos8, Krassimir Metodiev9, Sead Ahmetagic10, Arjan Harxhi11, Lul Raka12, Krsto Grozdanovski13, Mihai Nechifor14, Emine Alp15, Fatma Bozkurt16, Salih Hosoglu16, Ismail Balik17, Gulden Yilmaz17, Matjaz Jereb7, Fatemeh Moradi18, Nikolay Petrov19, Selcuk Kaya20, Iftihar Koksal20, Turan Aslan21, Nazif Elaldi22, Yasemin Akkoyunlu21, Seyyed Alireza Moravveji23, Gabor Csato24, Balazs Szedlak25, Filiz Akata26, Serkan Oncu27, Svjetlana Grgic28, Gorana Cosic29, Chavdar Stefanov30, Mehrdad Farrokhnia31, Mária Müller32, Catalina Luca14, Nada Koluder33, Volkan Korten34, Viliyan Platikanov35, Petja Ivanova35, Soheil Soltanipour36, Mahmood Vakili37, Saman Farahangiz38, Abdorrahim Afkhamzadeh39, Nicholas Beeching6, Salman Shaheer Ahmed15, Alma Cami40, Ramin Shiraly41, Anja Jazbec42, Tomislav Mirkovic43, Hakan Leblebicioglu44, Kurt Naber45. 1. GATA Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey. Electronic address: hakanerdem1969@yahoo.com. 2. Haydarpasa Numune Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey. 3. Sakarya University, Faculty of Management, Department of Health Administration, Sakarya, Turkey. 4. Clinical Center of Serbia (CCS), Department for Hospital Epidemiology, Belgrade, Serbia. 5. Department of Community Medicine, School of Medicine, Medicinal & Natural Products Chemistry Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. 6. Royal Liverpool University Hospital, United Kingdom. 7. University Medical Centre, Department of Infectious Diseases, Ljubljana, Slovenia. 8. Semmelweis University, Department of Anaesthesia and Intensive Care, Budapest, Hungary. 9. Medical University, Department of Preclinical and Clinical Sciences, Varna, Bulgaria. 10. University Clinical Center Tuzla, Department for Infectious Diseases, Tuzla, Bosnia and Herzegovina. 11. University Hospital Center of Tirana, Service of Infectious Disease, Tirana, Albania. 12. University of Prishtina, School of Medicine & National Institute of Public Health of Kosova, Prishtina, Kosova, Serbia. 13. University Clinic for Infectious Diseases, Department of Intensive Care, Skopje, Macedonia. 14. Gr. T. Popa University of Medicine and Pharmacy, Department of Pharmacology, Iasi, Romania. 15. Erciyes University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Kayseri, Turkey. 16. Dicle University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Diyarbakir, Turkey. 17. Ankara University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey. 18. Clinical Research Center on Infectious Diseases and Tropical Medicine, Bandar Abbas, Iran. 19. Military Medical Academy, Department Anaesthesiology and Intensive Care, Sofia, Bulgaria. 20. Karadeniz Technical University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, Turkey. 21. Bezmi Alem University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey. 22. Cumhuriyet University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Sivas, Turkey. 23. Kashan University of Medical Sciences, Trauma Research Center, Department of Community Medicine, Kashan, Iran. 24. Kenézy Hospital, Department of Anesthesiology and Intensive Care, Debrecen, Hungary. 25. Borsod County Hospital and Teaching Hospital, Department of Anaesthesiology and Intensive Therapy, Miskolc, Hungary. 26. Trakya University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Edirne, Turkey. 27. Adnan Menderes University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Aydin, Turkey. 28. University Hospital Clinic for Infectious Diseases, Mostar, Bosnia and Herzegovina. 29. IPH of Vojvodina, Department of Prevention and Control of Diseases, Medical Faculty, University of Novi Sad, Serbia. 30. University Multiprofile Hospital for Active Treatment, Department of Anesthesiology and Intensive Treatment, St. Georgi, Plovdiv, Bulgaria. 31. Kerman University of Medical Sciences, Department of Internal Medicine, Kerman, Iran. 32. Markhot Hospital, Department of Anaesthesiology and Intensive Care, Eger, Hungary. 33. Clinic for Infectious Diseases, Sarajevo, Bosnia and Herzegovina. 34. Marmara University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey. 35. University Hospital "St. Marina", Department of Anesthesiology and ICM, Varna, Bulgaria. 36. Guilan University of Medical Sciences, School of Medicine, Department of Community Medicine, Rasht, Iran. 37. Shahid Sadoughi University School of Medicine, Department of Community Medicine, Yazd, Iran. 38. Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 39. Department of Community Medicine, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. 40. University Hospital of Pulmonary Disease, Intensive Care Clinic, Tirana, Albania. 41. Ilam University of Medical Sciences, Department of Community Medicine, Yazd, Iran. 42. University Clinical Center Ljubljana, Center for Intensive Internal Medicine, Ljubljana, Slovenia. 43. University Medical Centre Ljubljana, Department of Anestesiology and Surgical Intensive Care, Ljubljana, Slovenia. 44. Ondokuz Mayis University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Samsun, Turkey. 45. Technical University of Munich, Munich, Germany.
Abstract
OBJECTIVE: We aimed to compare the features of intensive care units (ICUs), their antimicrobial resistance patterns, infection control policies, and distribution of infectious diseases from central Europe to Mid-West Asia. METHODS: A cross-sectional point prevalence study was performed in 88 ICUs from 12 countries. Characteristics of ICUs, patient and antibiotic therapy data were collected with a standard form by infectious diseases specialists. RESULTS: Out of 749, 305 patients at least with one infectious disease were assessed and 254 patients were reported to have coexistent medical problems. When primary infectious diseases diagnoses of the patients were evaluated, 69 had community-acquired, 61 had healthcare-associated, and 176 had hospital-acquired infections. Pneumonia was the most frequent ICU infection seen in half of the patients. Distribution of frequent pathogens was as follows: Enteric Gram-negatives (n = 62, 28.8%), Acinetobacter spp. (n = 47, 21.9%), Pseudomonas aeruginosa (n = 29, 13.5%). Multidrug resistance profiles of the infecting microorganisms seem to have a uniform pattern throughout Southern Europe and Turkey. On the other hand, active and device-associated infection surveillance was performed in Turkey more than Iran and Southeastern Europe (p < 0.05). However, designing antibiotic treatment according to culture results was highest in Southeastern Europe (p < 0.05). The most frequently used antibiotics were carbapenems (n = 92, 30.2%), followed by anti-gram positive agents (vancomycin, teicoplanin, linezolid, daptomycin, and tigecycline; n = 79, 25.9%), beta-lactam/beta lactamase inhibitors (n = 78, 25.6%), and extended-spectrum cephalosporins (n = 73, 23.9%). CONCLUSION: ICU features appears to have similar characteristics from the infectious diseases perspective, although variability seems to exist in this large geographical area.
OBJECTIVE: We aimed to compare the features of intensive care units (ICUs), their antimicrobial resistance patterns, infection control policies, and distribution of infectious diseases from central Europe to Mid-West Asia. METHODS: A cross-sectional point prevalence study was performed in 88 ICUs from 12 countries. Characteristics of ICUs, patient and antibiotic therapy data were collected with a standard form by infectious diseases specialists. RESULTS: Out of 749, 305 patients at least with one infectious disease were assessed and 254 patients were reported to have coexistent medical problems. When primary infectious diseases diagnoses of the patients were evaluated, 69 had community-acquired, 61 had healthcare-associated, and 176 had hospital-acquired infections. Pneumonia was the most frequent ICU infection seen in half of the patients. Distribution of frequent pathogens was as follows: Enteric Gram-negatives (n = 62, 28.8%), Acinetobacter spp. (n = 47, 21.9%), Pseudomonas aeruginosa (n = 29, 13.5%). Multidrug resistance profiles of the infecting microorganisms seem to have a uniform pattern throughout Southern Europe and Turkey. On the other hand, active and device-associated infection surveillance was performed in Turkey more than Iran and Southeastern Europe (p < 0.05). However, designing antibiotic treatment according to culture results was highest in Southeastern Europe (p < 0.05). The most frequently used antibiotics were carbapenems (n = 92, 30.2%), followed by anti-gram positive agents (vancomycin, teicoplanin, linezolid, daptomycin, and tigecycline; n = 79, 25.9%), beta-lactam/beta lactamase inhibitors (n = 78, 25.6%), and extended-spectrum cephalosporins (n = 73, 23.9%). CONCLUSION: ICU features appears to have similar characteristics from the infectious diseases perspective, although variability seems to exist in this large geographical area.
Authors: H Erdem; J P Stahl; A Inan; S Kilic; M Akova; C Rioux; I Pierre; A Canestri; E Haustraete; D O Engin; E Parlak; X Argemi; D Bruley; E Alp; S Greffe; S Hosoglu; S Patrat-Delon; Y Heper; M Tasbakan; V Corbin; M Hopoglu; I I Balkan; B Mutlu; E Demonchy; H Yilmaz; C Fourcade; L Toko-Tchuindzie; S Kaya; A Engin; A Yalci; C Bernigaud; H Vahaboglu; E Curlier; D Akduman; A Barrelet; S Oncu; V Korten; G Usluer; H Turgut; A Sener; O Evirgen; N Elaldi; L Gorenek Journal: Eur J Clin Microbiol Infect Dis Date: 2014-05-01 Impact factor: 3.267
Authors: S Tosun; A Batirel; A I Oluk; F Aksoy; E Puca; F Bénézit; S Ural; S Nayman-Alpat; T Yamazhan; V Koksaldi-Motor; R Tekin; E Parlak; P Tattevin; K Kart-Yasar; R Guner; A Bastug; M Meric-Koc; S Oncu; A Sagmak-Tartar; A Denk; F Pehlivanoglu; G Sengoz; S M Sørensen; G Celebi; L Baštáková; H Gedik; S Dirgen-Caylak; A Esmaoglu; S Erol; Y Cag; E Karagoz; A Inan; H Erdem Journal: Eur J Clin Microbiol Infect Dis Date: 2017-03-28 Impact factor: 3.267
Authors: Vu Dinh Phu; Heiman F L Wertheim; Mattias Larsson; Behzad Nadjm; Quynh-Dao Dinh; Lennart E Nilsson; Ulf Rydell; Tuyet Thi Diem Le; Son Hong Trinh; Hung Minh Pham; Cang Thanh Tran; Hanh Thi Hong Doan; Nguyen Thua Tran; Nhan Duc Le; Nhuan Van Huynh; Thao Phuong Tran; Bao Duc Tran; Son Truong Nguyen; Thao Thi Ngoc Pham; Tam Quang Dang; Chau Van Vinh Nguyen; Yen Minh Lam; Guy Thwaites; Kinh Van Nguyen; Hakan Hanberger Journal: PLoS One Date: 2016-01-29 Impact factor: 3.240