Literature DB >> 24269736

Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons.

A W Smith1, O K Rønnekleiv2, M J Kelly3.   

Abstract

Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  17β-Estradiol; Energy homeostasis; NPY/AgRP; POMC

Mesh：

Substances：

Year:  2013        PMID： 24269736      PMCID： PMC3951396          DOI： 10.1016/j.steroids.2013.11.007

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  74 in total

1.  Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations.

Authors:  Stephanie L Padilla; Daniel Reef; Lori M Zeltser
Journal:  Endocrinology       Date:  2011-12-13       Impact factor: 4.736

Review 2.  Desensitization of G protein-coupled receptors and neuronal functions.

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Journal:  Annu Rev Neurosci       Date:  2004       Impact factor: 12.449

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Journal:  Neuroendocrinology       Date:  1969       Impact factor: 4.914

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Journal:  Horm Behav       Date:  1975-12       Impact factor: 3.587

5.  Effects of hysterectomy on sexual receptivity, food intake, running wheel activity, and hypothalamic estrogen and progestin receptors in rats.

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Journal:  J Comp Physiol Psychol       Date:  1982-12

6.  The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol.

Authors:  A W Smith; M A Bosch; E J Wagner; O K Rønnekleiv; M J Kelly
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-07-02       Impact factor: 4.310

7.  Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility.

Authors:  Qi Wu; Benjamin B Whiddon; Richard D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-09       Impact factor: 11.205

8.  Sex differences in the activational effects of gonadal hormones on food intake and body weight.

Authors:  J A Czaja
Journal:  Physiol Behav       Date:  1984-10

9.  Similarities between morphine withdrawal in the rat and the menopausal hot flush.

Authors:  J W Simpkins; M J Katovich; I C Song
Journal:  Life Sci       Date:  1983-04-25       Impact factor: 5.037

10.  Intracranial estradiol in ovariectomized guinea pigs: effects on ingestive behaviors and body weight.

Authors:  P C Butera; J A Czaja
Journal:  Brain Res       Date:  1984-11-19       Impact factor: 3.252
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  9 in total

Review 1.  Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress.

Authors:  Nathalie Sumien; J Thomas Cunningham; Delaney L Davis; Rachel Engelland; Oluwadarasimi Fadeyibi; George E Farmer; Steve Mabry; Paapa Mensah-Kane; Oanh T P Trinh; Philip H Vann; E Nicole Wilson; Rebecca L Cunningham
Journal:  Endocrinology       Date:  2021-11-01       Impact factor: 5.051

Review 2.  Hypothalamic Estrogen Signaling and Adipose Tissue Metabolism in Energy Homeostasis.

Authors:  Valeria C Torres Irizarry; Yuwei Jiang; Yanlin He; Pingwen Xu
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-09       Impact factor: 6.055

3.  Membrane and nuclear initiated estrogenic regulation of homeostasis.

Authors:  Todd L Stincic; Oline K Rønnekleiv; Martin J Kelly
Journal:  Steroids       Date:  2019-06-20       Impact factor: 2.668

Review 4.  Membrane-initiated non-genomic signaling by estrogens in the hypothalamus: cross-talk with glucocorticoids with implications for behavior.

Authors:  Jennifer Rainville; Kevin Pollard; Nandini Vasudevan
Journal:  Front Endocrinol (Lausanne)       Date:  2015-02-16       Impact factor: 5.555

Review 5.  Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals.

Authors:  Alejandra Freire-Regatillo; Pilar Argente-Arizón; Jesús Argente; Luis Miguel García-Segura; Julie A Chowen
Journal:  Front Endocrinol (Lausanne)       Date:  2017-03-21       Impact factor: 5.555

6.  Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice.

Authors:  Todd L Stincic; Pasha Grachev; Martha A Bosch; Oline K Rønnekleiv; Martin J Kelly
Journal:  eNeuro       Date:  2018-10-10

7.  Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α.

Authors:  Shivani N Mann; Niran Hadad; Molly Nelson Holte; Alicia R Rothman; Roshini Sathiaseelan; Samim Ali Mondal; Martin-Paul Agbaga; Archana Unnikrishnan; Malayannan Subramaniam; John Hawse; Derek M Huffman; Willard M Freeman; Michael B Stout
Journal:  Elife       Date:  2020-12-08       Impact factor: 8.140

Review 8.  Estrogen Receptor Function: Impact on the Human Endometrium.

Authors:  Kun Yu; Zheng-Yuan Huang; Xue-Ling Xu; Jun Li; Xiang-Wei Fu; Shou-Long Deng
Journal:  Front Endocrinol (Lausanne)       Date:  2022-02-28       Impact factor: 5.555

9.  Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females.

Authors:  Jian Qiu; Heidi M Rivera; Martha A Bosch; Stephanie L Padilla; Todd L Stincic; Richard D Palmiter; Martin J Kelly; Oline K Rønnekleiv
Journal:  Elife       Date:  2018-08-06       Impact factor: 8.140
  9 in total

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