| Literature DB >> 24269700 |
László Képíró1, Márta Széll2, László Kovács3, Péter Keszthelyi4, Lajos Kemény5, Rolland Gyulai6.
Abstract
The aim of this study was to examine the role of single nucleotide polymorphisms (SNPs) and haplotypes of the tumor necrosis factor ligand superfamily member 15 (TNFSF15) gene in Hungarians with psoriasis and psoriatic arthritis. A case-control study was performed, and five TNFSF15 SNPs (rs3810936, rs6478108, rs6478109, rs7848647, rs7869487) were genotyped in 319 patients with psoriasis, 105 of whom also have psoriatic arthritis, and in 200 healthy individuals. Three haplotypes (A, B, C) based on these five SNPs were also analyzed. Our findings suggest that the rs6478109 SNP may be a genetic risk factor in psoriasis (p=0.0046), while haplotype C may be protective (p=0.0250). These results suggest that certain variants of the TNFSF15 gene contribute to the pathogenesis of the immune-mediated, multifactorial skin disease psoriasis, and that this difference is more readily apparent when groups of patients with and without psoriatic arthritis are examined separately.Entities:
Keywords: CASPAR; CD; Classification Criteria for Psoriatic Arthritis; Crohn’s disease; DR3; HLA; IBD; PASI; Psoriasis Area Severity Index; SNP; TL1A; TNF; TNF superfamily ligand A; TNFSF15; UC; VEGI; death domain receptor 3; human leukocyte antigen; inflammatory bowel disease; single nucleotide polymorphism; tumor necrosis factor; tumor necrosis factor superfamily, member 15; ulcerative colitis; vascular endothelial cell growth inhibitor
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Year: 2013 PMID： 24269700 DOI： 10.1016/j.humimm.2013.11.006
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850