Jae Hoon Jung1, Jong-Lyel Roh2, Jeong Hyun Lee3, Sung-Bae Kim4, Sang-Wook Lee5, Seung-Ho Choi1, Soon Yuhl Nam1, Sang Yoon Kim6. 1. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 2. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: rohjl@amc.seoul.kr. 3. Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 4. Department of Internal Medicine (Oncology), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 5. Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 6. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Abstract
OBJECTIVE: This study examined prognostic factors in patients with head and neck squamous cell carcinoma with advanced neck disease. STUDY DESIGN: The records of 191 patients with previously untreated head and neck squamous cell carcinoma and metastatic cervical lymph node (LN) >6 cm (cN, n = 70) and 3.01 to 6 cm (control, n = 121) in the greatest dimension were reviewed. Univariate and multivariate analyses were used to identify factors associated with disease-free survival (DFS) and locoregional control (LRC). RESULTS: In the cN3 group, independent variables for DFS were age, active drinking, LN size, and extranodal extension (P < .05), and that for LRC was age (P = .025). In the control group, independent variables for DFS were tumor location and differentiation and LN bilaterality (P < .05), and that for LRC was LN bilaterality (P = .011). CONCLUSIONS: The survival of cN3 patients is affected by host and nodal characteristics including age, drinking, nodal size, and extranodal extension.
OBJECTIVE: This study examined prognostic factors in patients with head and neck squamous cell carcinoma with advanced neck disease. STUDY DESIGN: The records of 191 patients with previously untreated head and neck squamous cell carcinoma and metastatic cervical lymph node (LN) >6 cm (cN, n = 70) and 3.01 to 6 cm (control, n = 121) in the greatest dimension were reviewed. Univariate and multivariate analyses were used to identify factors associated with disease-free survival (DFS) and locoregional control (LRC). RESULTS: In the cN3 group, independent variables for DFS were age, active drinking, LN size, and extranodal extension (P < .05), and that for LRC was age (P = .025). In the control group, independent variables for DFS were tumor location and differentiation and LN bilaterality (P < .05), and that for LRC was LN bilaterality (P = .011). CONCLUSIONS: The survival of cN3 patients is affected by host and nodal characteristics including age, drinking, nodal size, and extranodal extension.
Authors: Huaising C Ko; Shuai Chen; Aaron M Wieland; Menggang Yu; Andrew M Baschnagel; Gregory K Hartig; Paul M Harari; Matthew E Witek Journal: Head Neck Date: 2017-07-24 Impact factor: 3.147
Authors: Matthew E Witek; Aaron M Wieland; Shuai Chen; Tabassum A Kennedy; Craig R Hullett; Evan Liang; Gregory K Hartig; Randy J Kimple; Paul M Harari Journal: Cancers Head Neck Date: 2017-11-14