Literature DB >> 24268794

Towards cytotoxic and selective derivatives of maslinic acid.

Bianka Siewert1, Elke Pianowski1, Anja Obernauer1, René Csuk2.   

Abstract

Several novel esters and amides of maslinic acid were prepared. Their evaluation for cytotoxic activity with a panel of human cancer cell lines using a sulforhodamine B (SRB) assay revealed for some of them a noteworthy activity. The results from annexinV-FITC and caspase-assays as well as from DNA laddering experiments provided evidence for an apoptotic cell death. A diacetylated benzylamide (15) induced a G1/G0 arrest in tumor cells. It also displayed an extraordinary cytotoxicity against human ovarian cancer cells but a 300 times lower toxicity for non-malignant primary human fibroblasts.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Annexin V assay; Antitumor; Apoptosis; Cancer; Caspase activity; Cell cycle investigations; DNA laddering; Esters; Maslinic acid; SRB assay

Mesh：

Substances：

Year:  2013        PMID： 24268794     DOI： 10.1016/j.bmc.2013.10.047

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Madecassic Acid-A New Scaffold for Highly Cytotoxic Agents.

Authors:  Oliver Kraft; Ann-Kathrin Hartmann; Sophie Hoenke; Immo Serbian; René Csuk
Journal:  Int J Mol Sci       Date:  2022-04-14       Impact factor: 6.208

2.  Preparation and Applications of 4-Methoxybenzyl Esters in Organic Synthesis.

Authors:  Kyle T Howard; John D Chisholm
Journal:  Org Prep Proced Int       Date:  2016-01-29       Impact factor: 1.628

3.  In Vitro Evaluation of the Antimicrobial Ability and Cytotoxicity on Two Melanoma Cell Lines of a Benzylamide Derivative of Maslinic Acid.

Authors:  Ioana Zinuca Pavel; Corina Danciu; Camelia Oprean; Cristina Adriana Dehelean; Delia Muntean; René Csuk; Danina Mirela Muntean
Journal:  Anal Cell Pathol (Amst)       Date:  2016-12-05       Impact factor: 2.916

4.  Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity.

Authors:  Wei-Bin Mo; Chun-Hua Su; Jia-Yan Huang; Jun Liu; Zhen-Feng Chen; Ke-Guang Cheng
Journal:  Chem Cent J       Date:  2016-11-21       Impact factor: 4.215

5.  Assessment of the Antiangiogenic and Anti-Inflammatory Properties of a Maslinic Acid Derivative and its Potentiation using Zinc Chloride.

Authors:  Ioana Zinuca Pavel; Rene Csuk; Corina Danciu; Stefana Avram; Flavia Baderca; Andreea Cioca; Elena-Alina Moacă; Ciprian-Valentin Mihali; Iulia Pinzaru; Danina Mirela Muntean; Cristina Adriana Dehelean
Journal:  Int J Mol Sci       Date:  2019-06-10       Impact factor: 5.923

6.  Synthesis and Cytotoxic Activity of Novel C-23-Modified Asiatic Acid Derivatives.

Authors:  Yi-Hong Lu; Ming-Cang Chen; Fang Liu; Zhou Xu; Xiao-Ting Tian; Yang Xie; Cheng-Gang Huang
Journal:  Molecules       Date:  2020-08-14       Impact factor: 4.411

Review 7.  Mitocanic Di- and Triterpenoid Rhodamine B Conjugates.

Authors:  Sophie Hoenke; Immo Serbian; Hans-Peter Deigner; René Csuk
Journal:  Molecules       Date:  2020-11-20       Impact factor: 4.411

8.  Cytotoxic Potential of a-Azepano- and 3-Amino-3,4-SeCo-Triterpenoids.

Authors:  Oxana Kazakova; Irina Smirnova; Elena Tret'yakova; René Csuk; Sophie Hoenke; Lucie Fischer
Journal:  Int J Mol Sci       Date:  2021-02-08       Impact factor: 5.923

Review 9.  Current knowledge and development of hederagenin as a promising medicinal agent: a comprehensive review.

Authors:  Jia Zeng; Ting Huang; Man Xue; Jianxing Chen; Linglin Feng; Ruofei Du; Yi Feng
Journal:  RSC Adv       Date:  2018-07-03       Impact factor: 4.036
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.