| Literature DB >> 24267893 |
Jiwon Shim1, Tina Mukherjee, Bama Charan Mondal, Ting Liu, Gloria Chin Young, Dinali Priasha Wijewarnasuriya, Utpal Banerjee.
Abstract
Drosophila hematopoietic progenitor maintenance involves both near neighbor and systemic interactions. This study shows that olfactory receptor neurons (ORNs) function upstream of a small set of neurosecretory cells that express GABA. Upon olfactory stimulation, GABA from these neurosecretory cells is secreted into the circulating hemolymph and binds to metabotropic GABAB receptors expressed on blood progenitors within the hematopoietic organ, the lymph gland. The resulting GABA signal causes high cytosolic Ca(2+), which is necessary and sufficient for progenitor maintenance. Thus, the activation of an odorant receptor is essential for blood progenitor maintenance, and consequently, larvae raised on minimal odor environments fail to sustain a pool of hematopoietic progenitors. This study links sensory perception and the effects of its deprivation on the integrity of the hematopoietic and innate immune systems in Drosophila. PAPERCLIP:Entities:
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Year: 2013 PMID： 24267893 PMCID： PMC3865989 DOI： 10.1016/j.cell.2013.10.032
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582