Literature DB >> 24267885

Divergent transcription: a driving force for new gene origination?

Xuebing Wu1, Phillip A Sharp.   

Abstract

The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24267885      PMCID： PMC3899942          DOI： 10.1016/j.cell.2013.10.048

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  81 in total

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  86 in total

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Review 9.  Open questions in the study of de novo genes: what, how and why.

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