Literature DB >> 2426782

Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes.

A A Demetriou, J F Whiting, D Feldman, S M Levenson, N R Chowdhury, A D Moscioni, M Kram, J R Chowdhury.   

Abstract

Isolated hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion, can be attached to collagen-coated dextran microcarriers and transplanted by intraperitoneal injection into rats. Survival and function of the transplanted hepatocytes have been demonstrated in mutant rats lacking bilirubin-uridine diphosphate glucuronosyltransferase activity (Gunn strain) and rats with inherited lack of plasma albumin (Nagase analbuminemia rat strain). This simple technique promises to be useful in the treatment of acute liver failure in humans.

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Year:  1986        PMID： 2426782     DOI： 10.1126/science.2426782

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  40 in total

1.  Transplantation of primary and reversibly immortalized human liver cells and other gene therapies in acute liver failure and decompensated chronic liver disease.

Authors:  Stephen M Riordan; Roger Williams
Journal:  World J Gastroenterol       Date:  2000-10       Impact factor: 5.742

2.  Transplantation of human cells in the peritoneal cavity of immunodeficient mice for rapid assays of hepatitis B virus replication.

Authors:  Mukesh Kumar; Sriram Bandi; Kang Cheng; Sanjeev Gupta
Journal:  Xenotransplantation       Date:  2011 Nov-Dec       Impact factor: 3.907

Review 3.  Cellular transplantation and gene therapy.

Authors:  C Ricordi; S T Ildstad; T E Starzl
Journal:  Clin Transplant       Date:  1993-02       Impact factor: 2.863

4.  Clinical application of somatic gene therapy in inborn errors of metabolism.

Authors:  F D Ledley
Journal:  J Inherit Metab Dis       Date:  1990       Impact factor: 4.982

5.  Survival of human hepatocellular aggregates in athymic mice.

Authors:  C Ricordi; Y Zeng; B Carr; P Carroll; H L Rilo; A J Demetris; R Alejandro; D R Bereiter; J J Fung; A Tzakis
Journal:  Transplant Proc       Date:  1992-06       Impact factor: 1.066

6.  Evidence that canine pancreatic islets promote the survival of human hepatocytes in nude mice.

Authors:  C Ricordi; Y Zeng; A Tzakis; R Alejandro; A J Demetris; J Fung; D R Bereiter; D H Mintz; T E Starzl
Journal:  Transplantation       Date:  1991-10       Impact factor: 4.939

Review 7.  Hepatocyte transplantation. A potential treatment for liver disease.

Authors:  A A Demetriou; A Felcher; A D Moscioni
Journal:  Dig Dis Sci       Date:  1991-09       Impact factor: 3.199

8.  Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy.

Authors:  B Chevallay; D Herbage
Journal:  Med Biol Eng Comput       Date:  2000-03       Impact factor: 2.602

9.  Development of a hybrid bioartificial liver.

Authors:  J Rozga; M D Holzman; M S Ro; D W Griffin; D F Neuzil; T Giorgio; A D Moscioni; A A Demetriou
Journal:  Ann Surg       Date:  1993-05       Impact factor: 12.969

10.  An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice.

Authors:  Martha J Harding; Christin M Lepus; Thomas F Gibson; Benjamin R Shepherd; Scott A Gerber; Morven Graham; Frank X Paturzo; Christoph Rahner; Joseph A Madri; Alfred L M Bothwell; Brett D Lindenbach; Jordan S Pober
Journal:  PLoS One       Date:  2010-04-01       Impact factor: 3.240
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