Islet cell antigens. Initial studies of their biology and function.

Differentiation antigens expressed by pancreatic islet cells presumably play important roles in islet physiology and pathophysiology. We have developed a series of monoclonal antibody probes directed towards islet endocrine cells. Utilizing these antibodies we have identified and biochemically characterized several glycoprotein and glycolipid islet cell antigens. Many islet cell antibodies appear to react with unique carbohydrate residues on their antigen molecules. Islet cells share several monoclonal antibody-defined antigens and antigenic determinants with other neuroendocrine and related cell types. The detailed molecular structure, ontogeny, function and pathogenetic relevance of these islet antigens are being investigated.