Literature DB >> 24265380

Comment on: Wolpert et al. Dietary fat acutely increases glucose concentrations and insulin requirements in patients with type 1 diabetes: implications for carbohydrate-based bolus dose calculation and intensive diabetes management. Diabetes Care 2013;36:810-816.

Thomas M S Wolever1.   

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Year:  2013        PMID: 24265380      PMCID: PMC3836146          DOI: 10.2337/dc13-1173

Source DB:  PubMed          Journal:  Diabetes Care        ISSN: 0149-5992            Impact factor:   19.112


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I read with great interest the recent article by Wolpert et al. (1) in which they compared postprandial responses elicited by low- and high-fat dinner test meals and concluded that dietary fat increases glucose levels and insulin requirements in people with type 1 diabetes. This is consistent with recent results of ours showing that adding 20 g of fat as margarine to 110 g of bread (50 g starch) reduced the glycemic response in subjects without diabetes, but, if anything, tended to increase postprandial glucose in subjects with type 1 diabetes (2). We may have been unable to detect a significant increase in postprandial glucose because we added less than half the amount of fat to the test meal compared with Wolpert et al. (20 g vs. 50 g). Although Wolpert et al. performed a much more detailed, well-controlled, and sophisticated study than we did, they gave few details about the composition of the test meals; this makes comparison of their results with others in the literature difficult. Therefore, would Wolpert et al. please indicate the mean weight of the various foods in the low- and high-fat dinner test meals; the mean amounts of carbohydrate, dietary fiber, and protein; and, if possible, the nature of the fat they contained?
  2 in total

1.  Sugars and fat have different effects on postprandial glucose responses in normal and type 1 diabetic subjects.

Authors:  T M S Wolever; Y M Mullan
Journal:  Nutr Metab Cardiovasc Dis       Date:  2011-02-16       Impact factor: 4.222

2.  Dietary fat acutely increases glucose concentrations and insulin requirements in patients with type 1 diabetes: implications for carbohydrate-based bolus dose calculation and intensive diabetes management.

Authors:  Howard A Wolpert; Astrid Atakov-Castillo; Stephanie A Smith; Garry M Steil
Journal:  Diabetes Care       Date:  2012-11-27       Impact factor: 19.112

  2 in total

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