Literature DB >> 24264109

Metabolic effects of high doses of manganese in rats.

C L Keen1, D L Baly, B Lönnerdal.   

Abstract

The effects of acute manganese (Mn) toxicity on tissue manganese concentrations and on plasma glucose levels were investigated in adult male Sprague-Dawley rats. Manganese injection in all tissues analyzed was reflected by a significant increase in Mn concentration that was transitory. Changes in the molecular localization of Mn in liver following injection include both increases in protein-bound Mn and low molecular weight Mn complexes. A rapid, dose-responsive rise in blood glucose followed Mn injection, whereas circulating insulin levels decreased after injection. These data show that acute changes in tissue Mn levels can have a pronounced effect on carbohydrate metabolism.

Entities:  

Year:  1984        PMID： 24264109     DOI： 10.1007/BF02989238

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  10 in total

1.  [Transferrin or transmanganin? Definition of the manganese carrying protein in human plasma].

Authors:  A Foradori; M Dinamarca
Journal:  Rev Med Chil       Date:  1972-02       Impact factor: 0.553

2.  Pancreatic insulin release and peripheral tissue resistance in Zucker obese rats fed high- and low-carbohydrate diets.

Authors:  J S Stern; P R Johnson; B R Batchelor; L M Zucker; J Hirsch
Journal:  Am J Physiol       Date:  1975-02

3.  Acute manganese intoxication and pancreatitis in a patient treated with a contaminated dialysate.

Authors:  P A Taylor; J D Price
Journal:  Can Med Assoc J       Date:  1982-03-01       Impact factor: 8.262

4.  Role of liver lysosomes in uptake and biliary excretion of manganese in mice.

Authors:  H Suzuki; O Wada
Journal:  Environ Res       Date:  1981-12       Impact factor: 6.498

5.  Effect of manganese on some aspects of carbohydrate metabolism in rats.

Authors:  R Husain; M Mushtaq; P K Seth
Journal:  Bull Environ Contam Toxicol       Date:  1980-10       Impact factor: 2.151

6.  Chronic manganism: preliminary observations on glucose tolerance and serum proteins.

Authors:  M Hassanein; H A Ghaleb; E A Haroun; M R Hegazy; M A Khayyal
Journal:  Br J Ind Med       Date:  1966-01

7.  Manganese accumulation in pancreatic beta-cells and its stimulation by glucose.

Authors:  P Rorsman; P O Berggren; B Hellman
Journal:  Biochem J       Date:  1982-02-15       Impact factor: 3.857

8.  Effect of manganese deficiency on insulin secretion and carbohydrate homeostasis in rats.

Authors:  D L Baly; D L Curry; C L Keen; L S Hurley
Journal:  J Nutr       Date:  1984-08       Impact factor: 4.798

9.  Manganese effects on gluconeogenesis.

Authors:  R Rognstad
Journal:  J Biol Chem       Date:  1981-02-25       Impact factor: 5.157

10.  Influence of ashing techniques on the analysis of trace elements in animal tissue : I. Wet ashing.

Authors:  M S Clegg; C L Keen; B Lönnerdal; L S Hurley
Journal:  Biol Trace Elem Res       Date:  1981-06       Impact factor: 3.738
  10 in total
  4 in total

1.  Effects of manganese deficiency on pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity and carbohydrate homeostasis in adult rats.

Authors:  D L Baly; C L Keen; L S Hurley
Journal:  Biol Trace Elem Res       Date:  1986-12       Impact factor: 3.738

Review 2.  Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.

Authors:  Miles R Bryan; Aaron B Bowman
Journal:  Adv Neurobiol       Date:  2017

3.  Dietary intake of manganese and the risk of the metabolic syndrome in a Chinese population.

Authors:  Biao Zhou; Xuefen Su; Danting Su; Fangfang Zeng; Maggie Haitian Wang; Lichun Huang; Enshan Huang; Yibo Zhu; Dong Zhao; Denghua He; Xuhui Zhu; Engkiong Yeoh; Ronghua Zhang; Gangqiang Ding
Journal:  Br J Nutr       Date:  2016-07-07       Impact factor: 3.718

4.  Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice.

Authors:  Yongjuan Xin; Hong Gao; Jia Wang; Yuzhen Qiang; Mustapha Umar Imam; Yang Li; Jianyao Wang; Ruochen Zhang; Huizhen Zhang; Yingying Yu; Hao Wang; Haiyang Luo; Changhe Shi; Yuming Xu; Shintaro Hojyo; Toshiyuki Fukada; Junxia Min; Fudi Wang
Journal:  Cell Discov       Date:  2017-07-18       Impact factor: 10.849
  4 in total

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