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Literature DB >> 2426397

Relationship between platelet MAO activity and concentrations of 5-HIAA and HVA in cerebrospinal fluid in chronic pain patients.

L von Knorring, L Oreland, J Häggendal, T Magnusson, B Almay, F Johansson.

Abstract

Platelet monoamine oxidase (MAO) activity and concentrations of 5-HIAA and HVA in the cerebrospinal fluid (CSF) were estimated in a series of 54 chronic pain patients. Platelet MAO activity was found to correlate, positively to CSF concentrations of 5-HIAA and HVA, which had been adjusted in order to eliminate the influence of age and body height. However, only the correlation with 5-HIAA reached a significant level. When partial correlations were sought, only the positive correlation between platelet MAO activity and CSF 5-HIAA remained. The results support the notion that platelet MAO ia a biological marker for some trait dependent property of the central serotonergic system.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1986 PMID： 2426397 DOI： 10.1007/bf01262956

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

18 in total

1. Substrate- and inhibitor-related characteristics of human platelet monoamine oxidase.

Authors: C H Donnelly; D L Murphy
Journal: Biochem Pharmacol Date: 1977-05-01 Impact factor: 5.858

2. Some observations upon a new inhibitor of monoamine oxidase in brain tissue.

Authors: J P Johnston
Journal: Biochem Pharmacol Date: 1968-07 Impact factor: 5.858

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Authors: W J Freed; J E Kleinman; C N Karson; S G Potkin; D L Murphy; R J Wyatt
Journal: Biol Psychiatry Date: 1980-04 Impact factor: 13.382

4. Monoamine oxidase A and B: a useful concept?

Authors: T J Mantle; K F Tipton
Journal: Biochem Pharmacol Date: 1978-01-01 Impact factor: 5.858

5. The effect of age on the activity and molecular properties of human brain monoamine oxidase.

Authors: C J Fowler; A Wiberg; L Oreland; J Marcusson; B Winblad
Journal: J Neural Transm Date: 1980 Impact factor: 3.575

6. idiopathic pain disorder: a critique of pain-prone disorder and a proposal for a revision of the DSM-III category psychogenic pain disorder.

Authors: J B Williams; R L Spitzer
Journal: J Nerv Ment Dis Date: 1982-07 Impact factor: 2.254

7. Genetics of platelet MAO activity in discordant schizophrenic and normal twins.

Authors: M A Reveley; A M Reveley; C A Clifford; R M Murray
Journal: Br J Psychiatry Date: 1983-06 Impact factor: 9.319

8. Simultaneous determination of dopamine, DOPAC and homovanillic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography--electrochemical detection system.

Authors: O Magnusson; L B Nilsson; D Westerlund
Journal: J Chromatogr Date: 1980-12-12

Review 3. Idiopathic pain and depression.

Authors: L von Knorring; L Ekselius
Journal: Qual Life Res Date: 1994-12 Impact factor: 4.147

3 in total