Literature DB >> 2426361

Characterization of monoclonal antibodies specific for sequential influenza A/PR/8/34 virus variants.

M A Reale, A J Manheimer, T M Moran, G Norton, C A Bona, J L Schulman.   

Abstract

A panel of monoclonal antibodies specific for a corresponding panel of sequentially selected variants of influenza A/PR/8/34 virus has been established. Although the monoclonal antibodies are paratypically distinct, idiotypic relatedness has been observed. Two cross-reactive idiotypes have been defined that are associated with the 7183 and S107 VH gene families, respectively. Three of the four monoclonal antibodies utilize the VK21 group of light chains, and three VH genes belong to the VH7183 family and one to the VH S107 family. Antibodies encoded by genes deriving from the VH7183 family share a cross-reactive idiotype, a marker of the VH region as well as distinct individual idiotopes. These antibodies are produced by different clones using related VH and VK genes.

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Year:  1986        PMID： 2426361

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  11 in total

1.  Nucleotide changes in sequential variants of influenza virus hemagglutinin genes and molecular structures of corresponding monoclonal antibodies specific for each variant.

Authors:  K Meek; B Johansson; J Schulman; C Bona; J D Capra
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

2.  Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo.

Authors:  David J DiLillo; Gene S Tan; Peter Palese; Jeffrey V Ravetch
Journal:  Nat Med       Date:  2014-01-12       Impact factor: 53.440

3.  Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact.

Authors:  Paul E Leon; Wenqian He; Caitlin E Mullarkey; Mark J Bailey; Matthew S Miller; Florian Krammer; Peter Palese; Gene S Tan
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-19       Impact factor: 11.205

4.  A nine-segment influenza a virus carrying subtype H1 and H3 hemagglutinins.

Authors:  Qinshan Gao; Anice C Lowen; Taia T Wang; Peter Palese
Journal:  J Virol       Date:  2010-06-02       Impact factor: 5.103

5.  Generation, Characterization, and Applications of Influenza A Reporter Viruses.

Authors:  Kevin Chiem; Aitor Nogales; Luis Martinez-Sobrido
Journal:  Methods Mol Biol       Date:  2022

6.  High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains.

Authors:  B Bellon; A Manheimer-Lory; M Monestier; T Moran; A Dimitriu-Bona; F Alt; C Bona
Journal:  J Clin Invest       Date:  1987-04       Impact factor: 14.808

7.  Influenza A and B virus intertypic reassortment through compatible viral packaging signals.

Authors:  Steven F Baker; Aitor Nogales; Courtney Finch; Kevin M Tuffy; William Domm; Daniel R Perez; David J Topham; Luis Martínez-Sobrido
Journal:  J Virol       Date:  2014-07-09       Impact factor: 5.103

8.  A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo.

Authors:  Gene S Tan; Florian Krammer; Dirk Eggink; Alita Kongchanagul; Thomas M Moran; Peter Palese
Journal:  J Virol       Date:  2012-04-04       Impact factor: 5.103

9.  Generation and Characterization of Single-Cycle Infectious Canine Influenza A Virus (sciCIV) and Its Use as Vaccine Platform.

Authors:  Aitor Nogales; Kevin Chiem; Michael Breen; Marta L DeDiego; Colin R Parrish; Luis Martínez-Sobrido
Journal:  Methods Mol Biol       Date:  2022

10.  CD46 facilitates entry and dissemination of human cytomegalovirus.

Authors:  Kathryn R Stein; Thomas J Gardner; Rosmel E Hernandez; Thomas A Kraus; James A Duty; Iban Ubarretxena-Belandia; Thomas M Moran; Domenico Tortorella
Journal:  Nat Commun       Date:  2019-06-20       Impact factor: 14.919
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