Literature DB >> 24263188

bHLH-PAS proteins in cancer.

David C Bersten1, Adrienne E Sullivan, Daniel J Peet, Murray L Whitelaw.   

Abstract

Mammalian basic HLH (helix-loop-helix)-PER-ARNT-SIM (bHLH-PAS) proteins are heterodimeric transcription factors that sense and respond to environmental signals (such as pollutants) or to physiological signals (for example, hypoxia and circadian rhythms) through their two PAS domains. PAS domains form a generic three-dimensional fold, which commonly contains an internal cavity capable of small-molecule binding and outer surfaces adept at protein-protein interactions. These proteins are important in several pro-tumour and antitumour pathways and their activities can be modulated by both natural metabolites and oncometabolites. Recently determined structures and successful small-molecule screening programmes are now providing new opportunities to discover selective agonists and antagonists directed against this multitasking family of transcription factors.

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Year:  2013        PMID： 24263188     DOI： 10.1038/nrc3621

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  181 in total

1.  Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.

Authors:  Carrie L Partch; Kevin H Gardner
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-21       Impact factor: 11.205

2.  Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.

Authors:  Susan L Woods; Murray L Whitelaw
Journal:  J Biol Chem       Date:  2002-01-08       Impact factor: 5.157

3.  Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2.

Authors:  J Liang; L Prouty; B J Williams; M A Dayton; K L Blanchard
Journal:  Blood       Date:  1998-09-15       Impact factor: 22.113

4.  Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential.

Authors:  M B Kumar; G H Perdew
Journal:  Gene Expr       Date:  1999

5.  HIF-2alpha deletion promotes Kras-driven lung tumor development.

Authors:  Jolly Mazumdar; Michele M Hickey; Dhruv K Pant; Amy C Durham; Alejandro Sweet-Cordero; Anil Vachani; Tyler Jacks; Lewis A Chodosh; Joseph L Kissil; M Celeste Simon; Brian Keith
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-21       Impact factor: 11.205

6.  Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation.

Authors:  Shu Wang; Yuhui Yuan; Lan Liao; Shao-Qing Kuang; Jean Ching-Yi Tien; Bert W O'Malley; Jianming Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-24       Impact factor: 11.205

7.  Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.

Authors:  Kaname Kawajiri; Yasuhito Kobayashi; Fumiaki Ohtake; Togo Ikuta; Yoshibumi Matsushima; Junsei Mimura; Sven Pettersson; Richard S Pollenz; Toshiyuki Sakaki; Takatsugu Hirokawa; Tetsu Akiyama; Masafumi Kurosumi; Lorenz Poellinger; Shigeaki Kato; Yoshiaki Fujii-Kuriyama
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-27       Impact factor: 11.205

8.  Impact of the nuclear receptor coactivator AIB1 isoform AIB1-Delta3 on estrogenic ligands with different intrinsic activity.

Authors:  Ronald Reiter; Annabell S Oh; Anton Wellstein; Anna Tate Riegel
Journal:  Oncogene       Date:  2004-01-15       Impact factor: 9.867

9.  Allosteric inhibition of hypoxia inducible factor-2 with small molecules.

Authors:  Thomas H Scheuermann; Qiming Li; He-Wen Ma; Jason Key; Lei Zhang; Rui Chen; Joseph A Garcia; Jacinth Naidoo; Jamie Longgood; Doug E Frantz; Uttam K Tambar; Kevin H Gardner; Richard K Bruick
Journal:  Nat Chem Biol       Date:  2013-02-24       Impact factor: 15.040

10.  The genomic complexity of primary human prostate cancer.

Authors:  Michael F Berger; Michael S Lawrence; Francesca Demichelis; Yotam Drier; Kristian Cibulskis; Andrey Y Sivachenko; Andrea Sboner; Raquel Esgueva; Dorothee Pflueger; Carrie Sougnez; Robert Onofrio; Scott L Carter; Kyung Park; Lukas Habegger; Lauren Ambrogio; Timothy Fennell; Melissa Parkin; Gordon Saksena; Douglas Voet; Alex H Ramos; Trevor J Pugh; Jane Wilkinson; Sheila Fisher; Wendy Winckler; Scott Mahan; Kristin Ardlie; Jennifer Baldwin; Jonathan W Simons; Naoki Kitabayashi; Theresa Y MacDonald; Philip W Kantoff; Lynda Chin; Stacey B Gabriel; Mark B Gerstein; Todd R Golub; Matthew Meyerson; Ashutosh Tewari; Eric S Lander; Gad Getz; Mark A Rubin; Levi A Garraway
Journal:  Nature       Date:  2011-02-10       Impact factor: 49.962
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  98 in total

Review 1.  Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation.

Authors:  Troy D Hubbard; Iain A Murray; Gary H Perdew
Journal:  Drug Metab Dispos       Date:  2015-06-03       Impact factor: 3.922

Review 2.  Aryl hydrocarbon receptor ligands in cancer: friend and foe.

Authors:  Iain A Murray; Andrew D Patterson; Gary H Perdew
Journal:  Nat Rev Cancer       Date:  2014-12       Impact factor: 60.716

Review 3.  Hypoxia-inducible aryl hydrocarbon receptor nuclear translocator (ARNT) (HIF-1β): is it a rare exception?

Authors:  Markus Mandl; Reinhard Depping
Journal:  Mol Med       Date:  2014-05-27       Impact factor: 6.354

4.  Intragastric Administration of Casein Leads to Nigrostriatal Disease Progressed Accompanied with Persistent Nigrostriatal-Intestinal Inflammation Activited and Intestinal Microbiota-Metabolic Disorders Induced in MPTP Mouse Model of Parkinson's Disease.

Authors:  Xinrong Liu; Shuya Liu; Yong Tang; Zhengjia Pu; Hong Xiao; Jieying Gao; Qi Yin; Yan Jia; Qunhua Bai
Journal:  Neurochem Res       Date:  2021-03-15       Impact factor: 3.996

5.  Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein 2 Selectively Induces Stanniocalcin 2 Expression.

Authors:  Aditya D Joshi; Ekram Hossain; Cornelis J Elferink
Journal:  Mol Pharmacol       Date:  2017-07-10       Impact factor: 4.436

6.  Molecular modeling of the AhR structure and interactions can shed light on ligand-dependent activation and transformation mechanisms.

Authors:  Laura Bonati; Dario Corrada; Sara Giani Tagliabue; Stefano Motta
Journal:  Curr Opin Toxicol       Date:  2017-02-01

7.  Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle.

Authors:  Clara Bien Peek; Daniel C Levine; Jonathan Cedernaes; Akihiko Taguchi; Yumiko Kobayashi; Stacy J Tsai; Nicolle A Bonar; Maureen R McNulty; Kathryn Moynihan Ramsey; Joseph Bass
Journal:  Cell Metab       Date:  2016-10-20       Impact factor: 27.287

8.  Myeloid cell deletion of Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) induces non-alcoholic steatohepatitis.

Authors:  Christopher Scott; Rebecca Stokes; Kuan Minn Cha; Andrew Clouston; Mohammed Eslam; Mayda Metwally; Michael M Swarbrick; Jacob George; Jenny E Gunton
Journal:  PLoS One       Date:  2019-12-04       Impact factor: 3.240

Review 9.  The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction.

Authors:  Maria M Szwarc; Ramakrishna Kommagani; Bruce A Lessey; John P Lydon
Journal:  Biol Reprod       Date:  2014-10-08       Impact factor: 4.285

Review 10.  The role of hypoxia-inducible factors in metabolic diseases.

Authors:  Frank J Gonzalez; Cen Xie; Changtao Jiang
Journal:  Nat Rev Endocrinol       Date:  2018-12       Impact factor: 43.330
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