| Literature DB >> 24262783 |
Eduardo Pineda1, J David Jentsch2, Don Shin1, Grace Griesbach3, Raman Sankar4, Andrey Mazarati5.
Abstract
Attention deficit/hyperactivity disorder (ADHD) is encountered among patients with epilepsy at a significantly higher rate than in the general population. Mechanisms of epilepsy-ADHD comorbidity remain largely unknown. We investigated whether a model of chronic epilepsy in rats produces signs of ADHD, and thus, whether it can be used for studying mechanisms of this comorbidity. Epilepsy was induced in male Wistar rats via pilocarpine status epilepticus. Half of the animals exhibited chronic ADHD-like abnormalities, particularly increased impulsivity and diminished attention in the lateralized reaction-time task. These impairments correlated with the suppressed noradrenergic transmission in locus coeruleus outputs. The other half of animals exhibited depressive behavior in the forced swimming test congruently with the diminished serotonergic transmission in raphe nucleus outputs. Attention deficit/hyperactivity disorder and depressive behavior appeared mutually exclusive. Therefore, the pilocarpine model of epilepsy affords a system for reproducing and studying mechanisms of comorbidity between epilepsy and both ADHD and/or depression.Entities:
Keywords: 5-HT; ADHD; Attention deficit/hyperactivity disorder; Depression; EPMT; Epilepsy; FCV; FST; LC; LRTT; Lateralized reaction-time task; NE; Norepinephrine; PFC; RN; SE; Serotonin; TLE; attention deficit/hyperactivity disorder; elevated plus maze test; fast cyclic voltammetry; forced swimming test; lateralized reaction-time task; locus coeruleus; norepinephrine; prefrontal cortex; raphe nucleus; serotonin; status epilepticus; temporal lobe epilepsy
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Year: 2013 PMID： 24262783 PMCID： PMC3946735 DOI： 10.1016/j.yebeh.2013.10.004
Source DB: PubMed Journal: Epilepsy Behav ISSN： 1525-5050 Impact factor: 2.937