Literature DB >> 2426122

Ryanodine has no effect on the Ca current in single ventricular cells of guinea-pig.

M Nishio, S Kigoshi, I Muramatsu.   

Abstract

The Ca current was isolated and the effects of ryanodine were examined in Cs-loaded guinea-pig ventricular myocytes. The time course, amplitude and voltage dependence of the Ca current were not affected by the external or internal application of ryanodine, thereby suggesting that this alkaloid has no direct action on the Ca channel and that the inactivation of the Ca channel is not affected by Ca released from sarcoplasmic reticulum, at least under the present experimental conditions.

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Year:  1986        PMID： 2426122     DOI： 10.1016/0014-2999(86)90239-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Inactivation of ICa-L is the major determinant of use-dependent facilitation in rat cardiomyocytes.

Authors:  J Guo; H J Duff
Journal:  J Physiol       Date:  2003-01-31       Impact factor: 5.182

2.  Effects of ryanodine on skinned myocardial fibers of the rabbit.

Authors:  J Y Su
Journal:  Pflugers Arch       Date:  1988-02       Impact factor: 3.657

3.  Ryanodine inhibits the Ca-dependent K current after depletion of Ca stored in smooth muscle cells of the rabbit ileal longitudinal muscle.

Authors:  T Sakai; K Terada; K Kitamura; H Kuriyama
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

4.  Effects of goniopora toxin on the action potential and membrane currents of guinea-pig single ventricular cells.

Authors:  M Nishio; I Muramatsu; S Kigoshi; M Fujiwara
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-04       Impact factor: 3.000

5.  Intracellular N-methyl-D-glucamine modifies the kinetics and voltage-dependence of the calcium current in guinea pig ventricular heart cells.

Authors:  C O Malécot; P Feindt; W Trautwein
Journal:  Pflugers Arch       Date:  1988-03       Impact factor: 3.657

6.  Single ionic channels induced by palytoxin in guinea-pig ventricular myocytes.

Authors:  I Muramatsu; M Nishio; S Kigoshi; D Uemura
Journal:  Br J Pharmacol       Date:  1988-04       Impact factor: 8.739

7.  Somatostatin decreases the calcium inward current in guinea-pig atria.

Authors:  T Ohmura; M Nishio; S Kigoshi; I Muramatsu
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

8.  Effects of Ca2+ channel antagonists and ryanodine on H1-receptor mediated electromechanical response to histamine in guinea-pig left atria.

Authors:  Y Hattori; H Nakaya; N Tohse; M Kanno
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-03       Impact factor: 3.000
  8 in total

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