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Literature DB >> 24259411

Covalently coupled immunostimulant heterodimers.

Rock J Mancini¹, Janine K Tom, Aaron P Esser-Kahn.

Abstract

We report increased stimulation of dendritic cells via heterodimers of immunostimulants formed at a discrete molecular distance. Many vaccines present spatially organized agonists to immune cell receptors. These receptors cluster suggesting that signaling is increased by spatial organization and receptor proximity, but this has not been directly tested for multiple, unique receptors. In this study we probe the spatial aspect of immune cell activation using heterodimers of two covalently attached immunostimulants.

Entities: CellLine Chemical Disease Gene Species

Keywords: bioconjugation; dendritic cells; heterotelechelic polymers; immunology; vaccines

Mesh：

Substances：

Year: 2013 PMID： 24259411 PMCID： PMC4049977 DOI： 10.1002/anie.201306551

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

44 in total

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