BACKGROUND: Lopinavir/ritonavir (LPV/r) is associated with insulin resistance (IR). We aim to determine the prevalence of IR, dyslipidemia and their inter-relationships with adipokines in HIV-infected children treated with LPV/r-based highly active antiretroviral therapy (HAART). METHODS: Twenty-eight children were enrolled. Fasting glucose, insulin, lipid profiles, adipokines, and oral glucose tolerance tests were performed. RESULTS: The prevalence of IR, pre-diabetes mellitus, and hypertriglyceridemia was 42.9(12/28), 10.7(3/28), and 75.0(21/28)% respectively. No case met the definition for diabetes mellitus (DM) and lipodystrophy. Children with IR had higher BMI z-score, triglyceride levels but unchanged leptin or adiponectin levels compared to those without IR. Longer duration of LPV/r-based HAART was associated with increased levels of triglyceride and total cholesterol. CONCLUSIONS: We describe high prevalence of IR, pre-diabetes mellitus, and dyslipidemia among HIV-infected children receiving LPV/r-based HAART. Pre-diabetes mellitus or DM or IR screening might be important for early diagnosis and intervention in these children.
BACKGROUND:Lopinavir/ritonavir (LPV/r) is associated with insulin resistance (IR). We aim to determine the prevalence of IR, dyslipidemia and their inter-relationships with adipokines in HIV-infectedchildren treated with LPV/r-based highly active antiretroviral therapy (HAART). METHODS: Twenty-eight children were enrolled. Fasting glucose, insulin, lipid profiles, adipokines, and oral glucose tolerance tests were performed. RESULTS: The prevalence of IR, pre-diabetes mellitus, and hypertriglyceridemia was 42.9(12/28), 10.7(3/28), and 75.0(21/28)% respectively. No case met the definition for diabetes mellitus (DM) and lipodystrophy. Children with IR had higher BMI z-score, triglyceride levels but unchanged leptin or adiponectin levels compared to those without IR. Longer duration of LPV/r-based HAART was associated with increased levels of triglyceride and total cholesterol. CONCLUSIONS: We describe high prevalence of IR, pre-diabetes mellitus, and dyslipidemia among HIV-infectedchildren receiving LPV/r-based HAART. Pre-diabetes mellitus or DM or IR screening might be important for early diagnosis and intervention in these children.
Authors: Mitchell E Geffner; Kunjal Patel; Denise L Jacobson; Julia Wu; Tracie L Miller; Rohan Hazra; Mariana Gerschenson; Tanvi Sharma; Margarita Silio; Jennifer Jao; Jody K Takemoto; Russell B Van Dyke; Linda A DiMeglio Journal: AIDS Date: 2018-03-13 Impact factor: 4.177
Authors: Linda Barlow-Mosha; Victor Musiime; Mary-Ann Davies; Andrew J Prendergast; Philippa Musoke; George Siberry; Martina Penazzato Journal: J Int AIDS Soc Date: 2017-06-27 Impact factor: 5.396
Authors: Honoré Kalombayi Tshamala; Loukia Aketi; Pierre Manianga Tshibassu; Mathilde Bothale Ekila; Eric Musalu Mafuta; Patrick Kalambayi Kayembe; Michel Ntetani Aloni; Joseph Diayisu Shiku Journal: Int J Pediatr Date: 2019-03-03