BACKGROUND: Although line source attenuation correction (AC) in SPECT MPI studies improves diagnostic accuracy, its prognostic value is less understood. METHODS: Consecutive patients (n = 6,513) who underwent rest/stress AC ECG-gated SPECT MPI were followed for cardiac death or non-fatal myocardial infarction (MI). A 17-segment model and AC summed stress score (SSS) were used to classify images. RESULTS: Of the 6,513 patients, cardiac death or non-fatal MI occurred in 267 (4.1%), over 2.0 ± 1.4 years. The AC-SSS in patients with a cardiac event (5.6 ± 7.8) was significantly higher than in those without (1.9 ± 4.6, P < .001). The annualized cardiac event rate in patients with an AC-SSS 1-3 (3.6%) was significantly higher than in those with an AC-SSS = 0 (1.1%, P < .001) but similar to that in those with an AC-SSS 4-8 (2.9%, P = .4). Accordingly, patients were classified to AC-SSS = 0, 1-8, and >8 with annualized cardiac event rates of 1.1%, 3.2%, and 8.5%, respectively (P < .0001). In multivariate analysis, an AC-SSS 1-8 and >8 emerged as independent predictors of cardiac events (P < .02 and P < .0001, respectively). CONCLUSION: Rest/stress ECG-gated SPECT MPI with line source AC provides highly effective and incremental risk stratification for future cardiac events.
BACKGROUND: Although line source attenuation correction (AC) in SPECT MPI studies improves diagnostic accuracy, its prognostic value is less understood. METHODS: Consecutive patients (n = 6,513) who underwent rest/stress AC ECG-gated SPECT MPI were followed for cardiac death or non-fatal myocardial infarction (MI). A 17-segment model and AC summed stress score (SSS) were used to classify images. RESULTS: Of the 6,513 patients, cardiac death or non-fatal MI occurred in 267 (4.1%), over 2.0 ± 1.4 years. The AC-SSS in patients with a cardiac event (5.6 ± 7.8) was significantly higher than in those without (1.9 ± 4.6, P < .001). The annualized cardiac event rate in patients with an AC-SSS 1-3 (3.6%) was significantly higher than in those with an AC-SSS = 0 (1.1%, P < .001) but similar to that in those with an AC-SSS 4-8 (2.9%, P = .4). Accordingly, patients were classified to AC-SSS = 0, 1-8, and >8 with annualized cardiac event rates of 1.1%, 3.2%, and 8.5%, respectively (P < .0001). In multivariate analysis, an AC-SSS 1-8 and >8 emerged as independent predictors of cardiac events (P < .02 and P < .0001, respectively). CONCLUSION: Rest/stress ECG-gated SPECT MPI with line source AC provides highly effective and incremental risk stratification for future cardiac events.
Authors: Yasmin Masood; Yi-Hwa Liu; Gordon Depuey; Raymond Taillefer; Luis I Araujo; Steven Allen; Dominique Delbeke; Frank Anstett; Aharon Peretz; Mary-Jo Zito; Vera Tsatkin; Frans J Th Wackers Journal: J Nucl Cardiol Date: 2005 Nov-Dec Impact factor: 5.952
Authors: G V Heller; S D Herman; M I Travin; J I Baron; C Santos-Ocampo; J R McClellan Journal: J Am Coll Cardiol Date: 1995-11-01 Impact factor: 24.094
Authors: Sheeba Taneja; Hosahalli K Mohan; Glen M Blake; Lefteris Livieratos; Susan E M Clarke Journal: Nucl Med Commun Date: 2008-04 Impact factor: 1.690
Authors: Shishir Mathur; Gary V Heller; Timothy M Bateman; Richard Ruffin; Arshad Yekta; Deborah Katten; Nitya Alluri; Alan W Ahlberg Journal: J Nucl Cardiol Date: 2012-11-28 Impact factor: 5.952
Authors: Yuka Otaki; Julian Betancur; Tali Sharir; Lien-Hsin Hu; Heidi Gransar; Joanna X Liang; Peyman N Azadani; Andrew J Einstein; Mathews B Fish; Terrence D Ruddy; Philipp A Kaufmann; Albert J Sinusas; Edward J Miller; Timothy M Bateman; Sharmila Dorbala; Marcelo Di Carli; Balaji K Tamarappoo; Guido Germano; Damini Dey; Daniel S Berman; Piotr J Slomka Journal: JACC Cardiovasc Imaging Date: 2019-06-12
Authors: Manish Motwani; William D Leslie; Andrew L Goertzen; Yuka Otaki; Guido Germano; Daniel S Berman; Piotr J Slomka Journal: J Nucl Cardiol Date: 2017-03-13 Impact factor: 5.952
Authors: J D van Dijk; M Mouden; J P Ottervanger; J A van Dalen; S Knollema; C H Slump; P L Jager Journal: J Nucl Cardiol Date: 2016-01-15 Impact factor: 5.952