Literature DB >> 2425902

Toxin I from the snake Dendroaspis polylepis polylepis: a highly specific blocker of one type of potassium channel in myelinated nerve fiber.

E Benoit, J M Dubois.   

Abstract

Toxin I from the venom of the black mamba snake Dendroaspis polylepis polylepis specifically blocks one component of the K-current (IKf1) in the frog node of Ranvier, with a high affinity (Kd = 4 X 10(-10) M) without significantly affecting either the others components of the K current (IKf2 and IKs) or the Na-current. Moreover, for toxin concentrations corresponding to 10- or 100-fold the Kd value, the block was almost irreversible.

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Year:  1986        PMID： 2425902     DOI： 10.1016/0006-8993(86)90884-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  23 in total

Review 1.  Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.

Authors:  Dirk Bucher; Jean-Marc Goaillard
Journal:  Prog Neurobiol       Date:  2011-06-17       Impact factor: 11.685

Review 2.  Molecular properties of voltage-gated K+ channels.

Authors:  J O Dolly; D N Parcej
Journal:  J Bioenerg Biomembr       Date:  1996-06       Impact factor: 2.945

3.  Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels.

Authors:  P Jonas; M E Bräu; M Hermsteiner; W Vogel
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

4.  Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I.

Authors:  H Rehm; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

5.  Effects of the potassium channel blocking dendrotoxins on acetylcholine release and motor nerve terminal activity.

Authors:  A J Anderson; A L Harvey
Journal:  Br J Pharmacol       Date:  1988-01       Impact factor: 8.739

6.  The classic approach to the voltage-dependent K+-channel.

Authors:  H Rehm
Journal:  J Protein Chem       Date:  1989-06

Review 7.  An emerging pharmacology of peptide toxins targeted against potassium channels.

Authors:  E Moczydlowski; K Lucchesi; A Ravindran
Journal:  J Membr Biol       Date:  1988-10       Impact factor: 1.843

8.  Effects of a synthetic cationic polymer on sodium and potassium currents of frog nerve fibres.

Authors:  M Rack; G Drews
Journal:  Pflugers Arch       Date:  1989-04       Impact factor: 3.657

9.  Potassium currents in inner hair cells isolated from the guinea-pig cochlea.

Authors:  C J Kros; A C Crawford
Journal:  J Physiol       Date:  1990-02       Impact factor: 5.182

10.  Phloretin affects the fast potassium channels in frog nerve fibres.

Authors:  J Klusemann; H Meves
Journal:  Eur Biophys J       Date:  1991       Impact factor: 1.733
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