| Literature DB >> 2425801 |
T Amédée, J F Renaud, K Jmari, A Lombet, J Mironneau, M Lazdunski.
Abstract
This paper shows the presence, in rat myometrial smooth muscles, of low affinity binding sites for tetrodotoxin with a K0.5 value of 2 microM. Electrophysiological experiments using both intact strips and single isolated myometrial cells in culture have shown that veratridine and sea anemone toxins reveal functional Na+ channels. The activity of these channels was blocked by tetrodotoxin (10 microM) or by removal of Na+ ions. Results presented here are the first direct demonstration of the existence in rat myometrium of Na+ channels of the tetrodotoxin-resistant type.Entities:
Mesh：
Substances：
Year: 1986 PMID： 2425801 DOI： 10.1016/0006-291x(86)91131-9
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575