| Literature DB >> 24256579 |
Chao-Zhan Lin1, Zhong-Xiang Zhao2, Si-Min Xie2, Ju-Hua Mao2, Chen-Chen Zhu3, Xiao-Hui Li2, Bairi Zeren-dawa4, Kangsa Suolang-qimei4, Dun Zhu4, Tian-Qin Xiong2, Ai-Zhi Wu2.
Abstract
Five hetisane-type C20-diterpenoid alkaloids, trichodelphinines A-E, one delnudine-type C20-diterpenoid alkaloid, trichodelphinine F and three known flavonoids, quercetin, quercetin 3-O-β-D-glucopyranoside, and quercetin 3-O-β-D-glucopyranoside-7-O-α-L-arabinopyranoside, were isolated from whole plants of Delphinium trichophorum Franch. Their structures were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, NOESY and X-ray crystallographic analysis, and from chemical evidence. The cytotoxic activities of the diterpenoid alkaloids were evaluated using the MTT method, and the IC50 values of their cytotoxicity against A549 cancer cells ranged from 12.03 to 52.79 μM.Entities:
Keywords: Delnudine-type diterpenoid alkaloid; Delphinium trichophorum Franch; Diterpenoid alkaloid; Hetisane-type diterpenoid alkaloid; KRXFYFOHIOSSNE-ZXMOXNTFSA-N; Ranunculaceae; ULBJMFAWRDNRAM-JCTIUFQSSA-N; VPGOXBOVBANQMB-OQWYUALGSA-N; WDOZPTBXHDZRAC-GJGFCZQESA-N; WNZAQACNVGQHRH-NRNHFJSPSA-N; YPJJUKPGIAXPIU-RAXXLDHPSA-N
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Year: 2013 PMID： 24256579 DOI： 10.1016/j.phytochem.2013.10.011
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072