| Literature DB >> 24255943 |
Kazufumi Toume1, Kentaro Kamiya, Midori A Arai, Naomi Mori, Samir K Sadhu, Firoj Ahmed, Masami Ishibashi.
Abstract
Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.Entities:
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Year: 2013 PMID： 24255943 DOI： 10.1021/ol4029995
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005