Literature DB >> 2425568

Effects of antihistamines on isolated mast cells from the rat, guinea pig and man.

H Y Lau, F L Pearce.   

Abstract

The effects of a range of antihistamines and related compounds on mast cells from a number of different locations have been investigated. The drugs had a dual action on all the cell types examined: at high concentrations they induced histamine release while at low concentrations they inhibited the secretion of the amine evoked by antigen. The relative potencies of the various compounds in both evoking and preventing histamine release varied from one mast cell to another. In total, these studies then further emphasise the functional heterogeneity of mast cells from different locations.

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Year:  1986        PMID： 2425568     DOI： 10.1007/bf01987996

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  The anti-anaphylactic and histamine-releasing properties of the antihistamines. Their effect on the mast cells.

Authors:  I MOTA; W da SILVA
Journal:  Br J Pharmacol Chemother       Date:  1960-09

2.  Dual effect of antihistamines on rat peritoneal mast cells: induction and inhibition of histamine release.

Authors:  H Y Lau; F L Pearce
Journal:  Agents Actions       Date:  1985-04

3.  Some properties of mast cells obtained by human bronchoalveolar lavage.

Authors:  K B Leung; K C Flint; J Brostoff; B N Hudspith; N M Johnson; F L Pearce
Journal:  Agents Actions       Date:  1986-04

4.  Isolation and some properties of mast cells from the mesentery of the rat and guinea pig.

Authors:  F L Pearce; M Ennis
Journal:  Agents Actions       Date:  1980-04

5.  Functional heterogeneity of mast cells from different species and tissues.

Authors:  F L Pearce
Journal:  Klin Wochenschr       Date:  1982-09-01

6.  Characteristics of histamine secretion from rat peritoneal mast cells sensitized to the nematode Nippostrongylus brasiliensis.

Authors:  J R White; F L Pearce
Journal:  Immunology       Date:  1982-06       Impact factor: 7.397
  6 in total
  5 in total

1.  Effects of antihistamines on isolated rat peritoneal mast cells and on model membrane systems.

Authors:  H Y Lau; F L Pearce
Journal:  Agents Actions       Date:  1990-03

2.  A pharmacologic study on the histamine releasing effect of atracurium and other muscle relaxants in rat isolated ileum.

Authors:  F A Wali; A H Suer; E McAteer; A Hayter; A C Tugwell; V Makinde
Journal:  Agents Actions       Date:  1987-10

3.  The effects of urine on mast cells and smooth muscle of the human ureter.

Authors:  L Ugaily-Thulesius; O Thulesius
Journal:  Urol Res       Date:  1988

4.  The effect of a new antihistamine drug, Loderix (EGIS-2062), on stimulus-evoked histamine release from rat peritoneal mast cells.

Authors:  A Németh; Z Huszti
Journal:  Agents Actions       Date:  1988-04

5.  Circulatory depression and ventricular arrhythmias induced by compound 48/80 in anaesthetized rats.

Authors:  S Dai
Journal:  Agents Actions       Date:  1991-11
  5 in total

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