Literature DB >> 24254999

A chemical epitope-targeting strategy for protein capture agents: the serine 474 epitope of the kinase Akt2.

Arundhati Nag1, Samir Das, Mary Beth Yu, Kaycie M Deyle, Steven W Millward, James R Heath.   

Abstract

Entities:  

Keywords:  click chemistry; drug design; inhibitors; kinases; peptides

Mesh：

Substances：

Year:  2013        PMID： 24254999      PMCID： PMC4059071          DOI： 10.1002/anie.201305882

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  25 in total

1.  Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Authors:  D D Sarbassov; David A Guertin; Siraj M Ali; David M Sabatini
Journal:  Science       Date:  2005-02-18       Impact factor: 47.728

2.  Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.

Authors:  Yan Luo; Alexander R Shoemaker; Xuesong Liu; Keith W Woods; Sheela A Thomas; Ron de Jong; Edward K Han; Tongmei Li; Vincent S Stoll; Jessica A Powlas; Anatol Oleksijew; Michael J Mitten; Yan Shi; Ran Guan; Thomas P McGonigal; Vered Klinghofer; Eric F Johnson; Joel D Leverson; Jennifer J Bouska; Mulugeta Mamo; Richard A Smith; Emily E Gramling-Evans; Bradley A Zinker; Amanda K Mika; Phong T Nguyen; Tilman Oltersdorf; Saul H Rosenberg; Qun Li; Vincent L Giranda
Journal:  Mol Cancer Ther       Date:  2005-06       Impact factor: 6.261

3.  Rational design of inhibitors that bind to inactive kinase conformations.

Authors:  Yi Liu; Nathanael S Gray
Journal:  Nat Chem Biol       Date:  2006-07       Impact factor: 15.040

4.  Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.

Authors:  Craig W Lindsley; Zhijian Zhao; William H Leister; Ronald G Robinson; Stanley F Barnett; Deborah Defeo-Jones; Raymond E Jones; George D Hartman; Joel R Huff; Hans E Huber; Mark E Duggan
Journal:  Bioorg Med Chem Lett       Date:  2005-02-01       Impact factor: 2.823

Review 5.  The Akt/PKB pathway: molecular target for cancer drug discovery.

Authors:  Jin Q Cheng; Craig W Lindsley; George Z Cheng; Hua Yang; Santo V Nicosia
Journal:  Oncogene       Date:  2005-11-14       Impact factor: 9.867

6.  Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer.

Authors:  George V Thomas; Steve Horvath; Bradley L Smith; Katherine Crosby; Lori A Lebel; Matthew Schrage; Jonathan Said; Jean De Kernion; Robert E Reiter; Charles L Sawyers
Journal:  Clin Cancer Res       Date:  2004-12-15       Impact factor: 12.531

Review 7.  The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors.

Authors:  Craig W Lindsley; Stanley F Barnett; Mark E Layton; Mark T Bilodeau
Journal:  Curr Cancer Drug Targets       Date:  2008-02       Impact factor: 3.428

8.  Molecular recognition, fluorescence sensing, and biological assay of phosphate anion derivatives using artificial Zn(II)-Dpa complexes.

Authors:  Takashi Sakamoto; Akio Ojida; Itaru Hamachi
Journal:  Chem Commun (Camb)       Date:  2008-10-29       Impact factor: 6.222

9.  Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas.

Authors:  A Bellacosa; D de Feo; A K Godwin; D W Bell; J Q Cheng; D A Altomare; M Wan; L Dubeau; G Scambia; V Masciullo; G Ferrandina; P Benedetti Panici; S Mancuso; G Neri; J R Testa
Journal:  Int J Cancer       Date:  1995-08-22       Impact factor: 7.396

Review 10.  AKT/PKB signaling: navigating downstream.

Authors:  Brendan D Manning; Lewis C Cantley
Journal:  Cell       Date:  2007-06-29       Impact factor: 41.582
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  9 in total

1.  A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands.

Authors:  Samir Das; Arundhati Nag; JingXin Liang; David N Bunck; Aiko Umeda; Blake Farrow; Matthew B Coppock; Deborah A Sarkes; Amethist S Finch; Heather D Agnew; Suresh Pitram; Bert Lai; Mary Beth Yu; A Katrine Museth; Kaycie M Deyle; Bianca Lepe; Frances P Rodriguez-Rivera; Amy McCarthy; Belen Alvarez-Villalonga; Ann Chen; John Heath; Dimitra N Stratis-Cullum; James R Heath
Journal:  Angew Chem Int Ed Engl       Date:  2015-09-17       Impact factor: 15.336

Review 2.  Protein-Catalyzed Capture Agents.

Authors:  Heather D Agnew; Matthew B Coppock; Matthew N Idso; Bert T Lai; JingXin Liang; Amy M McCarthy-Torrens; Carmen M Warren; James R Heath
Journal:  Chem Rev       Date:  2019-03-06       Impact factor: 60.622

3.  Epitope targeting of tertiary protein structure enables target-guided synthesis of a potent in-cell inhibitor of botulinum neurotoxin.

Authors:  Blake Farrow; Michelle Wong; Jacquie Malette; Bert Lai; Kaycie M Deyle; Samir Das; Arundhati Nag; Heather D Agnew; James R Heath
Journal:  Angew Chem Int Ed Engl       Date:  2015-04-29       Impact factor: 15.336

4.  Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry.

Authors:  Ian Glassford; Christiana N Teijaro; Samer S Daher; Amy Weil; Meagan C Small; Shiv K Redhu; Dennis J Colussi; Marlene A Jacobson; Wayne E Childers; Bettina Buttaro; Allen W Nicholson; Alexander D MacKerell; Barry S Cooperman; Rodrigo B Andrade
Journal:  J Am Chem Soc       Date:  2016-02-26       Impact factor: 15.419

5.  Binding Characterization of Cyclic Peptide Ligands to Target Proteins and Chemical Epitopes Using ELISA and Fluorescence Polarization Assays.

Authors:  Ariane Borges; Iryna Onasenko; Arundhati Nag
Journal:  Methods Mol Biol       Date:  2022

6.  Degradation of Akt using protein-catalyzed capture agents.

Authors:  Ryan K Henning; Joseph O Varghese; Samir Das; Arundhati Nag; Grace Tang; Kevin Tang; Alexander M Sutherland; James R Heath
Journal:  J Pept Sci       Date:  2016-02-16       Impact factor: 1.905

7.  A protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH domain of Akt1.

Authors:  Kaycie M Deyle; Blake Farrow; Ying Qiao Hee; Jeremy Work; Michelle Wong; Bert Lai; Aiko Umeda; Steven W Millward; Arundhati Nag; Samir Das; James R Heath
Journal:  Nat Chem       Date:  2015-04-13       Impact factor: 24.427

Review 8.  Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope.

Authors:  Sinan Ma; Jianai Ji; Yuanyuan Tong; Yuxuan Zhu; Junwei Dou; Xian Zhang; Shicheng Xu; Tianbao Zhu; Xiaoli Xu; Qidong You; Zhengyu Jiang
Journal:  Acta Pharm Sin B       Date:  2022-02-26       Impact factor: 14.903

9.  Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease.

Authors:  Karina Reyes-Gordillo; Ruchi Shah; Jaime Arellanes-Robledo; Ying Cheng; Joseph Ibrahim; Pamela L Tuma
Journal:  Cells       Date:  2019-10-29       Impact factor: 6.600
  9 in total

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