Daniel Alcolea1, Pablo Martínez-Lage2, Andrea Izagirre3, Montserrat Clerigué3, María Carmona-Iragui1, Rosa María Alvarez4, Juan Fortea1, Mircea Balasa4, Estrella Morenas-Rodríguez1, Albert Lladó4, Oriol Grau4, Kaj Blennow5, Alberto Lleó1, José L Molinuevo4. 1. Department of Neurology, Inst. Investigacions Biomèdiques-Hospital Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, CIBERNED, Spain. 2. Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, CIBERNED, Spain Department of Neurology, Center for Research and Advanced Therapies, Fundación CITA-Alzheimer Fundazioa, San Sebastián, Spain. 3. Department of Neurology, Center for Research and Advanced Therapies, Fundación CITA-Alzheimer Fundazioa, San Sebastián, Spain. 4. Department of Neurology, Alzheimer's Disease and other Cognitive Disorders Unit, Hospital Clínic, Barcelona, Spain. 5. Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Göteborg, Göteborg, Sweden.
Abstract
BACKGROUND: Lumbar puncture (LP) is increasingly performed in memory units due to the usefulness of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease. The feasibility of this procedure in this context, however, is controversial. OBJECTIVE: Our aim was to analyze the incidence of complications and their associated factors so as to determine the impact of LP in the study of CSF biomarkers of Alzheimer's disease. METHODS: In the context of a larger international initiative, we prospectively collected data from 689 participants who underwent LP in three memory units in Spain. Data included demographic factors, headache history, subjective attitude toward the procedure, patient positioning, needle characteristics, volume of CSF extracted, attempts needed, and resting time after CSF acquisition. Five to seven days after the procedure, we asked participants about complications through a semi-structured telephone interview. RESULTS: No adverse events were reported in 441 (64.0%) participants. The most frequent complication was headache, reported by 171 (24.8%) subjects. It was severe in only 17 (2.5%). Headache was more frequent in younger participants and when a cutting-edge needle was used. Back pain was present in 111 (16.1%) cases, and it was associated with female gender, cutting-edge needles, increased number of attempts, and longer resting time after LP. No major complications were reported. The use of pen-point needles showed a trend toward a higher frequency of hematic CSF. CONCLUSION: LP can be safely performed to study CSF biomarkers. The main complication is headache, associated with younger age and use of cutting-edge needles.
BACKGROUND: Lumbar puncture (LP) is increasingly performed in memory units due to the usefulness of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease. The feasibility of this procedure in this context, however, is controversial. OBJECTIVE: Our aim was to analyze the incidence of complications and their associated factors so as to determine the impact of LP in the study of CSF biomarkers of Alzheimer's disease. METHODS: In the context of a larger international initiative, we prospectively collected data from 689 participants who underwent LP in three memory units in Spain. Data included demographic factors, headache history, subjective attitude toward the procedure, patient positioning, needle characteristics, volume of CSF extracted, attempts needed, and resting time after CSF acquisition. Five to seven days after the procedure, we asked participants about complications through a semi-structured telephone interview. RESULTS: No adverse events were reported in 441 (64.0%) participants. The most frequent complication was headache, reported by 171 (24.8%) subjects. It was severe in only 17 (2.5%). Headache was more frequent in younger participants and when a cutting-edge needle was used. Back pain was present in 111 (16.1%) cases, and it was associated with female gender, cutting-edge needles, increased number of attempts, and longer resting time after LP. No major complications were reported. The use of pen-point needles showed a trend toward a higher frequency of hematic CSF. CONCLUSION: LP can be safely performed to study CSF biomarkers. The main complication is headache, associated with younger age and use of cutting-edge needles.
Authors: Marissa D Zwan; Juha O Rinne; Steen G Hasselbalch; Agneta Nordberg; Alberto Lleó; Sanna-Kaisa Herukka; Hilkka Soininen; Ian Law; Justyna M C Bahl; Stephen F Carter; Juan Fortea; Rafael Blesa; Charlotte E Teunissen; Femke H Bouwman; Bart N M van Berckel; Pieter J Visser Journal: Neurology Date: 2015-10-14 Impact factor: 9.910
Authors: Neha Prakash; Chelsea Caspell-Garcia; Christopher Coffey; Andrew Siderowf; Caroline M Tanner; Karl Kieburtz; Brit Mollenhauer; Douglas Galasko; Kalpana Merchant; Tatiana Foroud; Lana M Chahine; Daniel Weintraub; Cindy Casaceli; Ray Dorsey; Renee Wilson; Margaret Herzog; Nichole Daegele; Vanessa Arnedo; Mark Frasier; Todd Sherer; Ken Marek; Samuel Frank; Danna Jennings; Tanya Simuni Journal: Parkinsonism Relat Disord Date: 2019-01-31 Impact factor: 4.891
Authors: A Leuzy; N J Ashton; N Mattsson-Carlgren; A Dodich; M Boccardi; J Corre; A Drzezga; A Nordberg; R Ossenkoppele; H Zetterberg; K Blennow; G B Frisoni; V Garibotto; O Hansson Journal: Eur J Nucl Med Mol Imaging Date: 2021-03-05 Impact factor: 9.236
Authors: Maria Carmona-Iragui; Daniel Alcolea; Isabel Barroeta; Laura Videla; Laia Muñoz; Kathyrn L Van Pelt; Frederick A Schmitt; Donita D Lightner; Lisa M Koehl; Gregory Jicha; Silvia Sacco; Clotilde Mircher; Sarah E Pape; Rosalyn Hithersay; Isabel C H Clare; Anthony J Holland; Georg Nübling; Johannes Levin; Shahid H Zaman; Andre Strydom; Anne-Sophie Rebillat; Elizabeth Head; Rafael Blesa; Alberto Lleó; Juan Fortea Journal: Lancet Neurol Date: 2021-08 Impact factor: 59.935
Authors: Angela A Botros; Narayan Schuetz; Christina Röcke; Robert Weibel; Mike Martin; René M Müri; Tobias Nef Journal: Sensors (Basel) Date: 2022-04-04 Impact factor: 3.576
Authors: Lih-Fen Lue; Marwan N Sabbagh; Ming-Jang Chiu; Naomi Jing; Noelle L Snyder; Christopher Schmitz; Andre Guerra; Christine M Belden; Ta-Fu Chen; Che-Chuan Yang; Shieh-Yueh Yang; Douglas G Walker; Kewei Chen; Eric M Reiman Journal: Front Aging Neurosci Date: 2017-07-24 Impact factor: 5.750
Authors: Sebastiaan Engelborghs; Ellis Niemantsverdriet; Hanne Struyfs; Kaj Blennow; Raf Brouns; Manuel Comabella; Irena Dujmovic; Wiesje van der Flier; Lutz Frölich; Daniela Galimberti; Sharmilee Gnanapavan; Bernhard Hemmer; Erik Hoff; Jakub Hort; Ellen Iacobaeus; Martin Ingelsson; Frank Jan de Jong; Michael Jonsson; Michael Khalil; Jens Kuhle; Alberto Lleó; Alexandre de Mendonça; José Luis Molinuevo; Guy Nagels; Claire Paquet; Lucilla Parnetti; Gerwin Roks; Pedro Rosa-Neto; Philip Scheltens; Constance Skårsgard; Erik Stomrud; Hayrettin Tumani; Pieter Jelle Visser; Anders Wallin; Bengt Winblad; Henrik Zetterberg; Flora Duits; Charlotte E Teunissen Journal: Alzheimers Dement (Amst) Date: 2017-05-18
Authors: Dobromira Z Tsvetkova; Sharon H Bergquist; Monica W Parker; Thomas L Jarrett; Jennifer C Howell; Kelly D Watts; Alexander Kollhoff; David L Roberts; William T Hu Journal: Front Aging Neurosci Date: 2017-02-10 Impact factor: 5.750
Authors: Alan Rembach; Lisbeth A Evered; Qiao-Xin Li; Tabitha Nash; Lesley Vidaurre; Christopher J Fowler; Kelly K Pertile; Rebecca L Rumble; Brett O Trounson; Sarah Maher; Francis Mooney; Maree Farrow; Kevin Taddei; Stephanie Rainey-Smith; Simon M Laws; S Lance Macaulay; William Wilson; David G Darby; Ralph N Martins; David Ames; Steven Collins; Brendan Silbert; Colin L Masters; James D Doecke Journal: Alzheimers Res Ther Date: 2015-11-19 Impact factor: 6.982