Ultrasensitive radioisotope, stable-isotope, and trace-element analysis in the biological sciences using tandem accelerator mass spectrometry.

The new technique of tandem accelerator mass spectrometry (TAMS) has improved the sensitivity for measurement of several long-lived radioisotopes and certain stable isotopes by many orders of magnitude. Nuclear physics tandems and new small dedicated accelerators are now able to measure(14)C,(10)Be,(26)Al,(32)Si,(36)Cl,(41)Ca, and(129)I in natural materials. Sensitivities down to 10(5) atoms per sample can be achieved in favorable cases. By accelerating ions to MeV energies, one can eliminate molecules and uniquely identify the atomic numbers below 20. Although most applications to date have been in the earth sciences, the opportunity now exists for important new applications in biology and toxicology. Trace elements can be measured at the parts per billion (10(9)) level using a secondary ion mass spectrometry (SIMS) ion source. Radioactive tracer measurements can be made for elements, such as aluminum, for which there are no isotopes with suitable half-lives for conventional decay counting methods. For(14)C, counting times become much shorter and dose levels can be reduced.