Literature DB >> 24253764

Brittlestars contain highly sulfated chondroitin sulfates/dermatan sulfates that promote fibroblast growth factor 2-induced cell signaling.

Rashmi Ramachandra1, Ramesh B Namburi, Olga Ortega-Martinez, Xiaofeng Shi, Joseph Zaia, Sam T Dupont, Michael C Thorndyke, Ulf Lindahl, Dorothe Spillmann.   

Abstract

Glycosaminoglycans (GAGs) isolated from brittlestars, Echinodermata class Ophiuroidea, were characterized, as part of attempts to understand the evolutionary development of these polysaccharides. A population of chondroitin sulfate/dermatan sulfate (CS/DS) chains with a high overall degree of sulfation and hexuronate epimerization was the major GAG found, whereas heparan sulfate (HS) was below detection level. Enzymatic digestion with different chondroitin lyases revealed exceptionally high proportions of di- and trisulfated CS/DS disaccharides. The latter unit appears much more abundant in one of four individual species of brittlestars, Amphiura filiformis, than reported earlier in other marine invertebrates. The brittlestar CS/DS was further shown to bind to growth factors such as fibroblast growth factor 2 and to promote FGF-stimulated cell signaling in GAG-deficient cell lines in a manner similar to that of heparin. These findings point to a potential biological role for the highly sulfated invertebrate GAGs, similar to those ascribed to HS in vertebrates.

Entities:  

Keywords:  brittlestar; chondroitin sulfate; dermatan sulfate; fibroblast growth factor 2

Mesh:

Substances:

Year:  2013        PMID: 24253764      PMCID: PMC3907082          DOI: 10.1093/glycob/cwt100

Source DB:  PubMed          Journal:  Glycobiology        ISSN: 0959-6658            Impact factor:   4.313


  62 in total

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