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Literature DB >> 2425308

Calcium channel current inactivation is selectively modulated by menthol.

Abstract

The effect of menthol on Ca channel current inactivation was studied in identified Helix neurons. External application of menthol accelerated the Ca-dependent rapid phase of inactivation. Menthol restored a fast inactivation phase after the Ca-dependent inactivation had been removed by strongly buffering changes in intracellular free Ca or by using Ba ions as current carriers. The menthol-induced inactivation was unchanged by variations in intracellular free Ca. A sensitizing effect of menthol on Ca-dependent inactivation appeared unlikely. Instead the results indicate a modulating action of menthol on Ca inactivation.

Entities: Chemical

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Year: 1986 PMID： 2425308 DOI： 10.1016/0304-3940(86)90223-5

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

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Cited

15 in total

1. Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons.

Authors: A H Klein; C M Sawyer; K Takechi; A Davoodi; M A Ivanov; M I Carstens; E Carstens
Journal: Neuroscience Date: 2012-06-09 Impact factor: 3.590

2. Discharge pattern analysis suggests existence of a low-threshold calcium channel in cold receptors.

Authors: K Schäfer; H A Braun; L Rempe
Journal: Experientia Date: 1991-01-15

3. Ampullary electroreceptors in catfish (Teleostei): temperature dependence of stimulus transduction.

Authors: K Schäfer; H A Braun; F Bretschneider; P F Teunis; R C Peters
Journal: Pflugers Arch Date: 1990-09 Impact factor: 3.657

4. Novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity.

Authors: Amanda H Klein; Mirela Iodi Carstens; T Scott McCluskey; Guillaume Blancher; Christopher T Simons; Jay P Slack; Stefan Furrer; Earl Carstens
Journal: Chem Senses Date: 2011-04-21 Impact factor: 3.160

Calcium channel current inactivation is selectively modulated by menthol.

1. Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons.

2. Discharge pattern analysis suggests existence of a low-threshold calcium channel in cold receptors.

3. Ampullary electroreceptors in catfish (Teleostei): temperature dependence of stimulus transduction.

4. Novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity.

5. Voltage-dependent and calcium-dependent inactivation of calcium channel current in identified snail neurones.

6. Effect of menthol on two types of Ca currents in cultured sensory neurons of vertebrates.

7. Kinetics and selectivity of a low-voltage-activated calcium current in chick and rat sensory neurones.

8. A quantitative study of the dependence of feline cold receptor activity on the calcium concentration.

9. Site and mechanism of activation of proton-induced sodium current in chick dorsal root ganglion neurones.

10. Stimulation by menthol of Cl secretion via a Ca(2+)-dependent mechanism in canine airway epithelium.