Nick Kane1, Lesley Grocott2, Ros Kandler3, Sarah Lawrence3, Catherine Pang4. 1. The Grey Walter Department of Clinical Neurophysiology, Frenchay Hospital, Bristol BS16 1LE, United Kingdom. Electronic address: Nick.Kane@nbt.nhs.uk. 2. The Clinical Neurophysiology Department, University Hospital of North Staffordshire, ST4 6QG, United Kingdom. 3. The Department of Clinical Neurophysiology, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom. 4. The Department of Clinical Neurophysiology, University Hospital of Coventry and Warwickshire, CV2 2DX, United Kingdom.
Abstract
PURPOSE: To determine safety and efficacy of hyperventilation (HV) during electroencephalography (EEG). METHODS: We report the findings of a prospective multicentre National Service Evaluation of the occurrence of adverse events, seizures and interictal epileptiform discharges seen in association with HV during EEG, in a relatively unselected, largely out patient population of 3475 being investigated predominantly for possible epileptic seizures. RESULTS: Adverse events occurred rarely, and there were no reported significant cerebrovascular, cardiovascular or respiratory events. Of the 3170 patients suspected of 'epilepsy or possible epilepsy' 69 patients (2.2%) had seizures provoked by HV, but only one (0.03%) had a generalised tonic clonic seizure. The elicitation or increase of interictal epileptiform discharges (IEDs) was seen in 387 (12.2%) of the total 3170 patients with suspected epilepsy who hyperventilated. Furthermore 31 patients (0.9%) had psychogenic non-epileptic seizures. CONCLUSION: HV is rarely associated with adverse events, but contributes to the diagnosis and classification of seizure disorders in an appreciable proportion of patients with epilepsy and non-epileptic attacks. These findings confirm that HV in selected patients is a valid activation technique in diagnostic EEG, where the potential benefits out weigh the risks, and also provide information that may assist the informed consent process.
PURPOSE: To determine safety and efficacy of hyperventilation (HV) during electroencephalography (EEG). METHODS: We report the findings of a prospective multicentre National Service Evaluation of the occurrence of adverse events, seizures and interictal epileptiform discharges seen in association with HV during EEG, in a relatively unselected, largely out patient population of 3475 being investigated predominantly for possible epileptic seizures. RESULTS: Adverse events occurred rarely, and there were no reported significant cerebrovascular, cardiovascular or respiratory events. Of the 3170 patients suspected of 'epilepsy or possible epilepsy' 69 patients (2.2%) had seizures provoked by HV, but only one (0.03%) had a generalised tonic clonic seizure. The elicitation or increase of interictal epileptiform discharges (IEDs) was seen in 387 (12.2%) of the total 3170 patients with suspected epilepsy who hyperventilated. Furthermore 31 patients (0.9%) had psychogenic non-epileptic seizures. CONCLUSION: HV is rarely associated with adverse events, but contributes to the diagnosis and classification of seizure disorders in an appreciable proportion of patients with epilepsy and non-epileptic attacks. These findings confirm that HV in selected patients is a valid activation technique in diagnostic EEG, where the potential benefits out weigh the risks, and also provide information that may assist the informed consent process.
Authors: Cecilia Maria Veraar; Harald Rinösl; Karina Kühn; Keso Skhirtladze-Dworschak; Alessia Felli; Mohamed Mouhieddine; Johannes Menger; Ekaterina Pataraia; Hendrik Jan Ankersmit; Martin Dworschak Journal: Crit Care Date: 2019-12-30 Impact factor: 9.097
Authors: Aida de Arriba-Arnau; Antònia Dalmau Llitjos; Virginia Soria; Javier Labad; José Manuel Menchón; Mikel Urretavizcaya Journal: Neuropsychiatr Dis Treat Date: 2021-05-20 Impact factor: 2.570