| Literature DB >> 24252519 |
Meggan Bandrick1, Claudia Ariza-Nieto2, Samuel K Baidoo3, Thomas W Molitor4.
Abstract
Immunoglobulins and immune cells are critical components of colostral immunity; however, their transfer to and function in the neonate, especially maternal lymphocytes, is unclear. Cell-mediated and antibody-mediated immunity in sow blood and colostrum and piglet blood before (PS) and after (AS) suckling were assessed to investigate transfer and function of maternal immunity in the piglet. CD4, CD8, and γδ lymphocytes were found in sow blood and colostrum and piglet blood PS and AS; each had a unique T lymphocyte profile. Immunoglobulins were detected in sow blood, colostrum, and in piglet blood AS; the immunoglobulin profile of piglet serum AS mimicked that of sow serum. These results suggest selectivity in lymphocyte concentration into colostrum and subsequent lymphocyte transfer into the neonate, but that immunoglobulin transfer is unimpeded. Assessment of colostral natural killer activity and antigen-specific proliferation revealed that colostral cells are capable of influencing the innate and specific immune response of neonatal pigs. Published by Elsevier Ltd.Entities:
Keywords: 7-aminoactinomycin D; 7AAD; AMI; APC; AS; CFSE; CMC; CMI; Colostrum; ELISA; IgA; IgG; M. hyopneumoniae; Maternally derived immunity; Mycoplasma hyopneumoniae; NK; Neonate; PBMC; PS; Passive transfer; S:P ratio; Swine; T lymphocyte; after-suckling; antibody-mediated immunity; antigen presenting cell; carboxyfluorescein diacetate succinimidyl ester; cell-mediated immunity; colostral mononuclear cells; conA; concanavalin A; enzyme linked immunosorbant assay; immunoglobulin A; immunoglobulin G; natural killer; peripheral blood mononuclear cell; pre-suckling; sample to positive ratio
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Year: 2013 PMID： 24252519 PMCID： PMC3902642 DOI： 10.1016/j.dci.2013.11.005
Source DB: PubMed Journal: Dev Comp Immunol ISSN： 0145-305X Impact factor: 3.636