Lei Xu1, Xin Zhou2, Feng Jiang3, Lin Xu4, Rong Yin5. 1. The Fourth Clinical College of Nanjing Medical University, China; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, China. 2. Department of Oncology, First Clinical College of Nanjing Medical University, Nanjing 210029, China. 3. Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, China. 4. Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, China. Electronic address: xulin83cn@gmail.com. 5. Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, China. Electronic address: yinhero001@126.com.
Abstract
BACKGROUND: It has been suggested that the serine/threonine kinase 15 (STK15) T91A rs2273535 polymorphism is associated with susceptibility to cancer. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship. METHODS: PubMed was searched to select studies. Case-control studies containing available genotype frequencies of the STK15 rs2273535 polymorphism were chosen, and the odds ratio (OR) with its 95% confidence interval (CI) was utilized to assess the strength of association. RESULTS: 52 studies - including 34,057 cases and 40,839 controls - were identified. A significant effect of the STK15 rs2273535 polymorphism on cancer risk was found (AA vs. TT: OR=1.13, 95%CI=1.01-1.26, Pheterogeneity<0.001; AA vs. TA/TT: OR=1.12, 95%CI=1.02-1.22, Pheterogeneity<0.001; TA/AA vs. TT: OR=1.06, 95%CI=1.01-1.12, Pheterogeneity<0.001). Stratified analysis by cancer type revealed that the STK rs2273535 polymorphism may contribute to the risk of breast cancer (AA vs. TT: OR=1.21, 95%CI=1.01-1.44, Pheterogeneity=0.002), colorectal cancer (AA vs. TA/TT: OR=1.24, 95%CI=1.05-1.47, Pheterogeneity=0.124), and esophageal cancer (AA vs. TA/TT: OR=1.19, 95%CI=1.02-1.39, Pheterogeneity=0.148). Further subgroup analysis by ethnicity indicated that there was a statistically increased cancer risk in Asians (AA vs. TA/TT: OR=1.20, 95%CI=1.05-1.37, Pheterogeneity=0.004). CONCLUSION: This meta-analysis suggests that the STK15 rs2273535 polymorphism is a candidate gene polymorphism for cancer susceptibility, especially in Asian populations.
BACKGROUND: It has been suggested that the serine/threonine kinase 15 (STK15) T91A rs2273535 polymorphism is associated with susceptibility to cancer. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship. METHODS: PubMed was searched to select studies. Case-control studies containing available genotype frequencies of the STK15 rs2273535 polymorphism were chosen, and the odds ratio (OR) with its 95% confidence interval (CI) was utilized to assess the strength of association. RESULTS: 52 studies - including 34,057 cases and 40,839 controls - were identified. A significant effect of the STK15 rs2273535 polymorphism on cancer risk was found (AA vs. TT: OR=1.13, 95%CI=1.01-1.26, Pheterogeneity<0.001; AA vs. TA/TT: OR=1.12, 95%CI=1.02-1.22, Pheterogeneity<0.001; TA/AA vs. TT: OR=1.06, 95%CI=1.01-1.12, Pheterogeneity<0.001). Stratified analysis by cancer type revealed that the STK rs2273535 polymorphism may contribute to the risk of breast cancer (AA vs. TT: OR=1.21, 95%CI=1.01-1.44, Pheterogeneity=0.002), colorectal cancer (AA vs. TA/TT: OR=1.24, 95%CI=1.05-1.47, Pheterogeneity=0.124), and esophageal cancer (AA vs. TA/TT: OR=1.19, 95%CI=1.02-1.39, Pheterogeneity=0.148). Further subgroup analysis by ethnicity indicated that there was a statistically increased cancer risk in Asians (AA vs. TA/TT: OR=1.20, 95%CI=1.05-1.37, Pheterogeneity=0.004). CONCLUSION: This meta-analysis suggests that the STK15 rs2273535 polymorphism is a candidate gene polymorphism for cancer susceptibility, especially in Asian populations.
Authors: Yael P Mossé; Elizabeth Fox; David T Teachey; Joel M Reid; Stephanie L Safgren; Hernan Carol; Richard B Lock; Peter J Houghton; Malcolm A Smith; David Hall; Donald A Barkauskas; Mark Krailo; Stephan D Voss; Stacey L Berg; Susan M Blaney; Brenda J Weigel Journal: Clin Cancer Res Date: 2019-02-18 Impact factor: 12.531
Authors: Nicholas W Bateman; Christopher M Tarney; Tamara S Abulez; Brian L Hood; Kelly A Conrads; Ming Zhou; Anthony R Soltis; Pang-Ning Teng; Amanda Jackson; Chunqiao Tian; Clifton L Dalgard; Matthew D Wilkerson; Michael D Kessler; Zachary Goecker; Jeremy Loffredo; Craig D Shriver; Hai Hu; Michele Cote; Glendon J Parker; James Segars; Ayman Al-Hendy; John I Risinger; Neil T Phippen; Yovanni Casablanca; Kathleen M Darcy; G Larry Maxwell; Thomas P Conrads; Timothy D O'Connor Journal: iScience Date: 2021-12-23