Literature DB >> 2424871

TA10 and 2B3, two new alleles in the HLA-DQ region recognized by monoclonal antibodies.

G M Schreuder, H Maeda, F Koning, J D'Amaro.   

Abstract

The monoclonal antibodies (MoAbs) A10/13 and IIB3 were studied in parallel with routine HLA-DR typings. The specificities TA10 and 2B3, recognized by A10/13 and IIB3 MoAb, respectively, showed clear segregation in families and never occurred together on the same haplotype. TA10 and 2B3 appeared to be in perfect Hardy-Weinberg equilibrium. The TA10 specificity is DQw3 related and is in linkage disequilibrium with DR5 (DRw11 and DRw12) and it is also weakly associated with DR4. The 2B3 specificity is DQw1 related and it is in linkage disequilibrium with DR2, DR4, DRw9, and DRw13. The 2B3 and TA10 specificities appear to be alleles of a polymorphic system, closely related, but different from HLA-DQ.

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Year:  1986        PMID： 2424871     DOI： 10.1016/0198-8859(86)90041-8

Source DB:  PubMed          Journal:  Hum Immunol        ISSN： 0198-8859            Impact factor:   2.850


  9 in total

1.  Dissection of HLA class II haplotypes in HLA-DR4 homozygous individuals.

Authors:  M G Tilanus; B Morolli; M C van Eggermond; G M Schreuder; R R de Vries; M J Giphart
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

2.  A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.

Authors:  M J Sheehy; S J Scharf; J R Rowe; M H Neme de Gimenez; L M Meske; H A Erlich; B S Nepom
Journal:  J Clin Invest       Date:  1989-03       Impact factor: 14.808

3.  Immunochemistry of the HLA class II molecules isolated from a mouse cell transfected with DQ alpha and beta genes from a DR4 haplotype.

Authors:  N Tanigaki; R Tosi; J L Strominger; J Cooper
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

4.  HLA-DQw3 dissected by cloned alloreactive T cells.

Authors:  G Pawelec; P Wernet
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

5.  Molecular diversity of HLA-DQ. DQ alpha and beta chain isoelectric point differences and their relation to serologically defined HLA-DQ allospecificities.

Authors:  R E Bontrop; E J Baas; N Otting; G M Schreuder; M J Giphart
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

6.  Polymorphisms of DQ beta genes in HLA-DR4 haplotypes from healthy and diabetic individuals.

Authors:  V Henson; N Maclaren; W Riley; E K Wakeland
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

7.  Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility.

Authors:  G T Horn; T L Bugawan; C M Long; H A Erlich
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

8.  Deficiency of immunity to Mycobacterium avium that can be restored by allogeneic lymphocytes.

Authors:  J D Schot; D Elferink; H Hooijkaas; H J Neijens; R K Schuurman
Journal:  Clin Exp Immunol       Date:  1987-04       Impact factor: 4.330

9.  HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism.

Authors:  G M Schreuder; M G Tilanus; R E Bontrop; G J Bruining; M J Giphart; J J van Rood; R R de Vries
Journal:  J Exp Med       Date:  1986-09-01       Impact factor: 14.307
  9 in total

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