Literature DB >> 2424843

Neurotensin stimulates histamine release in in vivo skin 'blisters' in rats: an effect inhibited by cromolyn or somatostatin.

D E Cochrane, W Boucher, P Bibb.   

Abstract

Histamine release was directly measured in in vivo skin blisters in rats in response to the intradermal injection of the peptide neurotensin (NT). Histamine release increased as the concentration of NT was raised from 10(-11) to 10(-5) M. This response was rapid in onset and was inhibited by disodium cromoglycate or the peptide somatostatin (SIRF). The inhibitory effect of SIRF was rapid and was evident from 10(-12) to 10(-8) M SIRF. A similar inhibition was observed on isolated peritoneal mast cells. Histamine release in response to substance P was not inhibited by SIRF.

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Year:  1986        PMID： 2424843     DOI： 10.1159/000234057

Source DB:  PubMed          Journal:  Int Arch Allergy Appl Immunol        ISSN： 0020-5915


  7 in total

1.  Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells.

Authors:  M Vasiadi; A Therianou; K D Alysandratos; A Katsarou-Katsari; T Petrakopoulou; A Theoharides; E Papadavid; N Stavrianeas; C Antoniou; D Kalogeromitros; T C Theoharides
Journal:  Br J Dermatol       Date:  2012-05-14       Impact factor: 9.302

2.  Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process.

Authors:  Jill Donelan; William Boucher; Nikoletta Papadopoulou; Michael Lytinas; Dean Papaliodis; Paul Dobner; Theoharis C Theoharides
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-08       Impact factor: 11.205

3.  HMC-1 human mast cells synthesize neurotensin (NT) precursor, secrete bioactive NT-like peptide(s) and express NT receptor NTS1.

Authors:  David E Cochrane; Robert E Carraway; Kimberly Harrington; Melissa Laudano; Stephen Rawlings; Ross S Feldberg
Journal:  Inflamm Res       Date:  2011-09-17       Impact factor: 4.575

4.  Inhibitory effects of the neurotensin8-13 analogs Asp13-NT8-13 and Asp12-NT8-13 on mast cell secretion.

Authors:  L A Miller; D E Cochrane; R E Carraway; R S Feldberg
Journal:  Agents Actions       Date:  1993-01

Review 5.  Neuroendocrinology of the skin.

Authors:  Theoharis C Theoharides; Julia M Stewart; Alexandra Taracanova; Pio Conti; Christos C Zouboulis
Journal:  Rev Endocr Metab Disord       Date:  2016-09       Impact factor: 6.514

6.  Elevated serum neurotensin and CRH levels in children with autistic spectrum disorders and tail-chasing Bull Terriers with a phenotype similar to autism.

Authors:  I Tsilioni; N Dodman; A I Petra; A Taliou; K Francis; A Moon-Fanelli; L Shuster; T C Theoharides
Journal:  Transl Psychiatry       Date:  2014-10-14       Impact factor: 6.222

7.  Neurotensin and CRH interactions augment human mast cell activation.

Authors:  Konstantinos-Dionysios Alysandratos; Shahrzad Asadi; Asimenia Angelidou; Bodi Zhang; Nikolaos Sismanopoulos; Hailing Yang; Agatha Critchfield; Theoharis C Theoharides
Journal:  PLoS One       Date:  2012-11-14       Impact factor: 3.240
  7 in total

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