Kirsten V Knutsen1, Ahmed A Madar, Per Lagerløv, Mette Brekke, Truls Raastad, Lars C Stene, Haakon E Meyer. 1. Department of General Practice (K.V.K., P.L., M.B.), Institute of Health and Society, University of Oslo, Oslo N-0318, Norway; Department of Community Medicine (A.A.M., H.E.M.), Institute of Health and Society, University of Oslo, Oslo N-0318, Norway; Division of Epidemiology (L.C.S., H.E.M.), Norwegian Institute of Public Health, Oslo N-0403, Norway; and Norwegian School of Sport Sciences (T.R.), Oslo N-0806, Norway.
Abstract
CONTEXT: The effect of vitamin D on muscle strength in adults is not established. OBJECTIVE: Our objective was to test whether vitamin D supplementation increases muscle strength and power compared with placebo. DESIGN: We conducted a randomized, double-blind, placebo-controlled trial. SETTING: The setting was immigrants' activity centers. PARTICIPANTS: Two hundred fifty-one healthy adult males and females aged 18-50 years with non-Western immigrant background performed the baseline test and 86% returned to the follow-up test. INTERVENTIONS: Sixteen weeks of daily supplementation with 25 μg (1000 IU) vitamin D3, 10 μg (400 IU) vitamin D3, or placebo. MAIN OUTCOME MEASURES: Difference in jump height between pre- and postintervention. Secondary outcomes were differences in handgrip strength and chair-rising test. RESULTS: Percentage change in jump height did not differ between those receiving vitamin D (25 or 10 μg vitamin D3) and those receiving placebo (mean difference -1.4%, 95% confidence interval: -4.9% to 2.2%, P=.44). No significant effect was detected in the subgroup randomized to 25 μg vitamin D or in other preplanned subgroup analyses nor were there any significant differences in handgrip strength or the chair-rising test. Mean serum 25-hydroxyvitamin D3 concentration increased from 27 to 52 nmol/L and from 27 to 43 nmol/L in the 25 and 10 μg supplementation groups, respectively, whereas serum 25-hydroxyvitamin D3 did not change in the placebo group. CONCLUSIONS: Daily supplementation with 25 or 10 μg vitamin D3 for 16 weeks did not improve muscle strength or power measured by the jump test, handgrip test, or chair-rising test in this population with low baseline vitamin D status.
RCT Entities:
CONTEXT: The effect of vitamin D on muscle strength in adults is not established. OBJECTIVE: Our objective was to test whether vitamin D supplementation increases muscle strength and power compared with placebo. DESIGN: We conducted a randomized, double-blind, placebo-controlled trial. SETTING: The setting was immigrants' activity centers. PARTICIPANTS: Two hundred fifty-one healthy adult males and females aged 18-50 years with non-Western immigrant background performed the baseline test and 86% returned to the follow-up test. INTERVENTIONS: Sixteen weeks of daily supplementation with 25 μg (1000 IU) vitamin D3, 10 μg (400 IU) vitamin D3, or placebo. MAIN OUTCOME MEASURES: Difference in jump height between pre- and postintervention. Secondary outcomes were differences in handgrip strength and chair-rising test. RESULTS: Percentage change in jump height did not differ between those receiving vitamin D (25 or 10 μg vitamin D3) and those receiving placebo (mean difference -1.4%, 95% confidence interval: -4.9% to 2.2%, P=.44). No significant effect was detected in the subgroup randomized to 25 μg vitamin D or in other preplanned subgroup analyses nor were there any significant differences in handgrip strength or the chair-rising test. Mean serum 25-hydroxyvitamin D3 concentration increased from 27 to 52 nmol/L and from 27 to 43 nmol/L in the 25 and 10 μg supplementation groups, respectively, whereas serum 25-hydroxyvitamin D3 did not change in the placebo group. CONCLUSIONS: Daily supplementation with 25 or 10 μg vitamin D3 for 16 weeks did not improve muscle strength or power measured by the jump test, handgrip test, or chair-rising test in this population with low baseline vitamin D status.
Authors: J C Brown; J I Schall; R M Rutstein; M B Leonard; B S Zemel; V A Stallings Journal: J Musculoskelet Neuronal Interact Date: 2015-06 Impact factor: 2.041
Authors: Mirjam M Oosterwerff; Rosa Meijnen; Natasja M Van Schoor; Dirk L Knol; Mark H H Kramer; Mireille N M Van Poppel; Paul Lips; E Marelise W Eekhoff Journal: Endocr Connect Date: 2014-10-28 Impact factor: 3.335
Authors: Ahmed A Madar; Kirsten V Knutsen; Lars C Stene; Mette Brekke; Haakon E Meyer; Per Lagerløv Journal: BMJ Open Diabetes Res Care Date: 2014-10-13
Authors: Ahmed A Madar; Lars C Stene; Haakon E Meyer; Mette Brekke; Per Lagerløv; Kirsten V Knutsen Journal: Nutr J Date: 2016-08-09 Impact factor: 3.271