| Literature DB >> 2424768 |
S Carrel, P Isler, M Schreyer, A Vacca, S Salvi, L Giuffre, J P Mach.
Abstract
The expression on a significant number of thymocytes of idiotypic structures (Ti) restricted to HPB-ALL or Jurkat cells is demonstrated. As many as 2-4% of thymocytes were stained with anti-Ti HPB-ALL or anti-Ti Jurkat monoclonal antibodies, when analyzed by flow microfluorometry. Immunohistochemical localization studies performed on frozen thymus specimens of either fetal or pediatric origin indicated a scattered distribution of Ti-positive cells in both the cortex and the medulla. From lysates of 125I-labeled pediatric thymocytes, anti-Ti HPB-ALL and anti-Ti Jurkat monoclonal antibodies precipitated disulfide-linked heterodimers comparable to those precipitated from 125I-labeled HPB-ALL or Jurkat cells as shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis.Entities:
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Year: 1986 PMID： 2424768 DOI： 10.1002/eji.1830160610
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532