Improved event-related potential estimation using statistical pattern classification.

A new method of ERP estimation with minimal statistical assumptions is presented. A mathematical pattern classification procedure is used to select trials with discriminable event-related signals in a time interval of interest. A method of forming a reference 'baseline' is also presented. Stimulus-registered and response-registered 'enhanced' ERP averages computed from selected trials of a visuo-motor experiment show substantial enhancement of event-related signals, especially for channels with weak signals, while rejected trials have minimal event-related signals.