Diversin increases the proliferation and invasion ability of non-small-cell lung cancer cells via JNK pathway.

The expression and significance of Diversin in human tumors remains unclear. We found that Diversin was overexpressed in NSCLC, and exhibited direct correlation to poor differentiation, advanced TNM stage, lymph node metastasis and survival time. Overexpression of Diversin lead to a significant increase in proliferation and invasion of NSCLC cells, possibly through activation of JNK, cyclin B and MMP9, and the effects were blocked by JNK inhibitor. These results suggest Diversin is overexpressed in NSCLC and predict poor prognosis. Diversin may promote cell proliferation and invasion through JNK pathway.