Literature DB >> 24246418

Polygenic risk for Alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people.

Sarah E Harris1, Gail Davies2, Michelle Luciano3, Antony Payton4, Helen C Fox5, Paul Haggarty6, William Ollier4, Michael Horan7, David J Porteous1, John M Starr8, Lawrence J Whalley5, Neil Pendleton7, Ian J Deary3.   

Abstract

Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ.

Entities:  

Keywords:  Aging; Alzheimer's disease; cognition; cohort studies; genetics; polygenic traits

Mesh：

Substances：

Year:  2014        PMID： 24246418     DOI： 10.3233/JAD-131058

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  21 in total

1.  Using an Alzheimer Disease Polygenic Risk Score to Predict Memory Decline in Black and White Americans Over 14 Years of Follow-up.

Authors:  Jessica R Marden; Elizabeth R Mayeda; Stefan Walter; Alexandre Vivot; Eric J Tchetgen Tchetgen; Ichiro Kawachi; M Maria Glymour
Journal:  Alzheimer Dis Assoc Disord       Date:  2016 Jul-Sep       Impact factor: 2.703

2.  Association of Alzheimer's related genotypes with cognitive decline in multiple domains: results from the Three-City Dijon study.

Authors:  A Vivot; M M Glymour; C Tzourio; P Amouyel; G Chêne; C Dufouil
Journal:  Mol Psychiatry       Date:  2015-06-02       Impact factor: 15.992

3.  Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.

Authors:  Burcu F Darst; Rebecca L Koscik; Annie M Racine; Jennifer M Oh; Rachel A Krause; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Bradley T Christian; Barbara B Bendlin; Ozioma C Okonkwo; Kirk J Hogan; Bruce P Hermann; Mark A Sager; Sanjay Asthana; Sterling C Johnson; Corinne D Engelman
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

4.  Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E.

Authors:  Shraddha Sapkota; David Vergote; David Westaway; Jack Jhamandas; Roger A Dixon
Journal:  Neurobiol Aging       Date:  2014-06-20       Impact factor: 4.673

Review 5.  Genetic variants in Alzheimer disease - molecular and brain network approaches.

Authors:  Chris Gaiteri; Sara Mostafavi; Christopher J Honey; Philip L De Jager; David A Bennett
Journal:  Nat Rev Neurol       Date:  2016-06-10       Impact factor: 42.937

Review 6.  Gene-based aggregate SNP associations between candidate AD genes and cognitive decline.

Authors:  Jasmine Nettiksimmons; Gregory Tranah; Daniel S Evans; Jennifer S Yokoyama; Kristine Yaffe
Journal:  Age (Dordr)       Date:  2016-03-22

Review 7.  Progress in Polygenic Composite Scores in Alzheimer's and Other Complex Diseases.

Authors:  Danai Chasioti; Jingwen Yan; Kwangsik Nho; Andrew J Saykin
Journal:  Trends Genet       Date:  2019-03-25       Impact factor: 11.639

8.  Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition.

Authors:  Tian Ge; Mert R Sabuncu; Jordan W Smoller; Reisa A Sperling; Elizabeth C Mormino
Journal:  Neurology       Date:  2018-03-28       Impact factor: 9.910

9.  The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.

Authors:  Michelle K Lupton; Lachlan Strike; Narelle K Hansell; Wei Wen; Karen A Mather; Nicola J Armstrong; Anbupalam Thalamuthu; Katie L McMahon; Greig I de Zubicaray; Amelia A Assareh; Andrew Simmons; Petroula Proitsi; John F Powell; Grant W Montgomery; Derrek P Hibar; Eric Westman; Magda Tsolaki; Iwona Kloszewska; Hilkka Soininen; Patrizia Mecocci; Bruno Velas; Simon Lovestone; Henry Brodaty; David Ames; Julian N Trollor; Nicholas G Martin; Paul M Thompson; Perminder S Sachdev; Margaret J Wright
Journal:  Neurobiol Aging       Date:  2016-01-11       Impact factor: 4.673

10.  Polygenic risk of Alzheimer disease is associated with early- and late-life processes.

Authors:  Elizabeth C Mormino; Reisa A Sperling; Avram J Holmes; Randy L Buckner; Philip L De Jager; Jordan W Smoller; Mert R Sabuncu
Journal:  Neurology       Date:  2016-07-06       Impact factor: 9.910
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