OBJECTIVE: To demonstrate that xanthogranuloma is a rare cause of idiopathic central diabetes insipidus in the early phase of the disease and that it presents as a suprasellar mass at a later stage. In addition, we emphasize the importance of identifying the cause of idiopathic central diabetes insipidus and review the literature concerning endocrine disturbance in central xanthogranuloma. METHODS: Review of recently published case reports of central xanthogranuloma with endocrine disorders. The case of a 35-year-old man who presented with a very large suprasellar mass is also reported. The patient was diagnosed with idiopathic central diabetes insipidus 20 years ago with normal brain magnetic resonance imaging. RESULTS: Most cases of this disease present as supra- or parasellar masses with endocrine involvement, the most common of which (in approximately 75% of patients) is sex hormone deficiency. Diabetes insipidus was found in 65% of patients. CONCLUSION: Xanthogranuloma should be in the differential diagnosis of idiopathic central diabetes insipidus and sellar and parasellar masses. A detailed skin examination is very important in making the diagnosis of central diabetes insipidus.
OBJECTIVE: To demonstrate that xanthogranuloma is a rare cause of idiopathic central diabetes insipidus in the early phase of the disease and that it presents as a suprasellar mass at a later stage. In addition, we emphasize the importance of identifying the cause of idiopathic central diabetes insipidus and review the literature concerning endocrine disturbance in central xanthogranuloma. METHODS: Review of recently published case reports of central xanthogranuloma with endocrine disorders. The case of a 35-year-old man who presented with a very large suprasellar mass is also reported. The patient was diagnosed with idiopathic central diabetes insipidus 20 years ago with normal brain magnetic resonance imaging. RESULTS: Most cases of this disease present as supra- or parasellar masses with endocrine involvement, the most common of which (in approximately 75% of patients) is sex hormone deficiency. Diabetes insipidus was found in 65% of patients. CONCLUSION:Xanthogranuloma should be in the differential diagnosis of idiopathic central diabetes insipidus and sellar and parasellar masses. A detailed skin examination is very important in making the diagnosis of central diabetes insipidus.
Authors: M Stojanovic; E Manojlovic-Gacic; S Pekic; T Milojevic; D Miljic; M Doknic; M Nikolic Djurovic; Z Jemuovic; M Petakov Journal: Acta Endocrinol (Buchar) Date: 2019 Apr-Jun Impact factor: 0.877
Authors: Vera Lozovanu; Carmen Emanuela Georgescu; Lavinia Maria Florescu; Carmen Georgiu; Horatiu Silaghi; Andrian Fratea; Cristina Alina Silaghi Journal: J Pers Med Date: 2022-06-08
Authors: Jaya Sujatha Gopal-Kothandapani; Veejay Bagga; Stephen B Wharton; Daniel J Connolly; Saurabh Sinha; Paul J Dimitri Journal: Endocrinol Diabetes Metab Case Rep Date: 2015-01-01