| Literature DB >> 24245558 |
Diana Haas1, Marc Mosrin, Paul Knochel.
Abstract
A general method for the synthesis of 2,4,5-trisubstituted oxazoles has been developed. Starting from commercially available oxazole, successive metalations using TMPMgCl·LiCl or TMPZnCl·LiCl led to the corresponding magnesiated or zincated species which were stable toward ring fragmentation. Furthermore, they readily reacted with various electrophiles, such as aryl and allylic halides, acid chlorides, TMSCl, and TMS-CN, providing highly functionalized oxazoles.Entities:
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Year: 2013 PMID： 24245558 DOI： 10.1021/ol403019c
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005