Literature DB >> 2424511

Isobutyl cyanoacrylate nanoparticles as a solid phase for an efficient immunoradiometric assay.

L Manil, L Roblot-Treupel, P Couvreur.   

Abstract

The interaction of monoclonal antibodies and seric proteins with cyanoacrylic nanoparticles was investigated. A high binding capacity, rapid kinetics of adsorption as well as a good stability of the linkage were found. Furthermore, the immunoreactivity was conserved after coating antibody to nanoparticles. A new competitive immunoradiometric assay was also proposed for determination of alpha-fetoprotein amounts as low as 0.1 ng per assay.

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Year:  1986        PMID： 2424511     DOI： 10.1016/0142-9612(86)90105-5

Source DB:  PubMed          Journal:  Biomaterials        ISSN： 0142-9612            Impact factor:   12.479


  3 in total

1.  Radiolabelled monoclonal antibodies against alpha-fetoprotein for in vivo localization of human hepatocellular carcinoma by immunotomoscintigraphy.

Authors:  J F Bergmann; J D Lumbroso; L Manil; J C Saccavini; P Rougier; M Assicot; A Mathieu; D Bellet; C Bohuon
Journal:  Eur J Nucl Med       Date:  1987

2.  Is anti-alphafetoprotein immunoscintigraphy a promising approach for the diagnosis of hepatoma? Implications of a quantitative study in 41 patients.

Authors:  J L Demangeat; L Manil; C Demangeat; E Rico; C Staedel-Flaig; B Duclos; B Brunot; D Jaeck; D Bellet; A Constantinesco
Journal:  Eur J Nucl Med       Date:  1988

3.  Uptake of nanoparticles by rat glomerular mesangial cells in vivo and in vitro.

Authors:  L Manil; J C Davin; C Duchenne; C Kubiak; J Foidart; P Couvreur; P Mahieu
Journal:  Pharm Res       Date:  1994-08       Impact factor: 4.200
  3 in total

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