Literature DB >> 2424465

Oxidized low density lipoprotein induces ceroid accumulation by murine peritoneal macrophages in vitro.

R Y Ball, J P Bindman, K L Carpenter, M J Mitchinson.   

Abstract

The presence of ceroid pigment inclusions within macrophage foam cells is a well-recognized phenomenon in human atherosclerosis but its significance is unclear. Murine peritoneal macrophages, maintained in a medium containing 10% lipoprotein-deficient fetal calf serum to which oxidized low density lipoprotein (LDL) has been added, rapidly accumulate similar ceroid inclusions. However, cells exposed to LDL, acetyl--LDL or dextran sulphate--LDL complexes fail to develop ceroid under the same culture conditions. Oxidation of LDL results in considerable physico-chemical changes to both protein and lipid moieties, and these may be important in the uptake of the particles by macrophages and, subsequently, the accumulation of intracellular ceroid.

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Year:  1986        PMID： 2424465     DOI： 10.1016/0021-9150(86)90009-2

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  14 in total

1.  Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues.

Authors:  John W Crabb; June O'Neil; Masaru Miyagi; Karen West; Henry F Hoff
Journal:  Protein Sci       Date:  2002-04       Impact factor: 6.725

2.  Mechanism of ceroid formation in atherosclerotic plaque: in situ studies using a combination of Raman and fluorescence spectroscopy.

Authors:  Abigail S Haka; John R Kramer; Ramachandra R Dasari; Maryann Fitzmaurice
Journal:  J Biomed Opt       Date:  2011 Jan-Feb       Impact factor: 3.170

3.  Ceroid accumulation by murine peritoneal macrophages exposed to artificial lipoproteins: ultrastructural observations.

Authors:  R Y Ball; K L Carpenter; M J Mitchinson
Journal:  Br J Exp Pathol       Date:  1988-02

4.  Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages.

Authors:  G Hoppe; J O'Neil; H F Hoff
Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808

5.  Ceroid accumulation by murine peritoneal macrophages exposed to artificial lipid-containing particles: the role of the hydrophilic component.

Authors:  K M Ardeshna; R Y Ball; K L Carpenter; J H Enright; M J Mitchinson
Journal:  Int J Exp Pathol       Date:  1990-12       Impact factor: 1.925

6.  Glucose oxidation and low-density lipoprotein-induced macrophage ceroid accumulation: possible implications for diabetic atherosclerosis.

Authors:  J V Hunt; M A Bottoms; K Clare; J T Skamarauskas; M J Mitchinson
Journal:  Biochem J       Date:  1994-05-15       Impact factor: 3.857

7.  The diagnosis and management of arteritis.

Authors:  N D Karanjia; S J Cawthorn; A E Giddings
Journal:  J R Soc Med       Date:  1993-05       Impact factor: 5.344

8.  Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper.

Authors:  K L Carpenter; G M Wilkins; B Fussell; J A Ballantine; S E Taylor; M J Mitchinson; D S Leake
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

9.  Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice. Association with aortic fatty streak development.

Authors:  J H Qiao; C L Welch; P Z Xie; M C Fishbein; A J Lusis
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

10.  Oxygen radicals and atherosclerosis.

Authors:  K L Carpenter; C E Brabbs; M J Mitchinson
Journal:  Klin Wochenschr       Date:  1991-12-15
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