BACKGROUND: Recommended screening to identify children at risk for diabetes and its precursors impaired glucose tolerance (IGT) and insulin resistance (IR) is fasted plasma glucose (FPG). This study evaluates the added value of fasted plasma insulin (FPI). METHODS: This study analyzed routinely collected data of an oral glucose tolerance test (OGTT) of 311 obese children (age 10.8 ± 3.2 years). Diabetes and IGT were defined according to the American Diabetes Association criteria, IR as homeostasis model assessment (HOMA)-IR ≥3.4. RESULTS: Cases diagnosed with an OGTT if FPG ≥5.6 mmol/L, compared with an OGTT performed if FPG ≥5.6 mmol/L or HOMA-IR ≥3.4, were, respectively, 4 (80%) versus 5 (100%) with diabetes, 7 (28%) versus 16 (64%) with IGT, and 0 (0%) versus 93 (100%) with IR. CONCLUSIONS: Screening with FPG and FPI has equal burden compared with screening with FPG alone, identifies all patients with diabetes, and identifies more patients with precursors of diabetes.
BACKGROUND: Recommended screening to identify children at risk for diabetes and its precursors impaired glucose tolerance (IGT) and insulin resistance (IR) is fasted plasma glucose (FPG). This study evaluates the added value of fasted plasma insulin (FPI). METHODS: This study analyzed routinely collected data of an oral glucose tolerance test (OGTT) of 311 obesechildren (age 10.8 ± 3.2 years). Diabetes and IGT were defined according to the American Diabetes Association criteria, IR as homeostasis model assessment (HOMA)-IR ≥3.4. RESULTS: Cases diagnosed with an OGTT if FPG ≥5.6 mmol/L, compared with an OGTT performed if FPG ≥5.6 mmol/L or HOMA-IR ≥3.4, were, respectively, 4 (80%) versus 5 (100%) with diabetes, 7 (28%) versus 16 (64%) with IGT, and 0 (0%) versus 93 (100%) with IR. CONCLUSIONS: Screening with FPG and FPI has equal burden compared with screening with FPG alone, identifies all patients with diabetes, and identifies more patients with precursors of diabetes.
Authors: Y E Lentferink; M P van der Aa; E G A H van Mill; C A J Knibbe; M M J van der Vorst Journal: Nutr Diabetes Date: 2018-09-10 Impact factor: 5.097
Authors: Soulmaz Fazeli Farsani; Marloes P van der Aa; Catherijne A J Knibbe; Anthonius de Boer; Marja M J van der Vorst Journal: Glob Pediatr Health Date: 2015-01-19
Authors: Lidewij T Warris; Erica L T van den Akker; Marc B Bierings; Cor van den Bos; Christian M Zwaan; Sebastiaan D T Sassen; Wim J E Tissing; Margreet A Veening; Rob Pieters; Marry M van den Heuvel-Eibrink Journal: PLoS One Date: 2016-06-30 Impact factor: 3.240
Authors: Anabel Flores; Lawrence S Argetsinger; Lukas K J Stadler; Alvaro E Malaga; Paul B Vander; Lauren C DeSantis; Ray M Joe; Joel M Cline; Julia M Keogh; Elana Henning; Ines Barroso; Edson Mendes de Oliveira; Gowri Chandrashekar; Erik S Clutter; Yixin Hu; Jeanne Stuckey; I Sadaf Farooqi; Martin G Myers; Christin Carter-Su Journal: Diabetes Date: 2019-08-22 Impact factor: 9.461