Literature DB >> 24241960

Ki67 and TP53 expressions predict recurrence of non-muscle-invasive bladder cancer.

Lujia Wang1, Chenchen Feng, Guanxiong Ding, Qiang Ding, Zhongwen Zhou, Haowen Jiang, Zhong Wu.   

Abstract

Tumor markers Ki67, TP53, and TP63 are common labels in the diagnosis of bladder cancer (BCa) around the world. The combination of those biomarkers may have advantages in predicting BCa prognosis and non-muscle-invasive bladder cancer (NMIBC) postoperative recurrence. We investigated the immunohistochemical profiles of 313 bladder cancer samples classified under the WHO/ISUP (2004) grading scale and the UICC-TNM (2002) classification. Then we investigated their predictive value in the tumor recurrence of 270 NMIBC patients after TURBT. Expression of Ki67 correlates with grade, stage, tumor size, and tumor numbers. Semiquantitative evaluation of TP53 correlates with grade and invasive conditions. The positive expression rate of TP63 correlated with tumor grade and stage. The combined effect of TP53 and Ki67 revealed a predictive value in NMIBC recurrence. However, the positive TP63 expression did not show any protective effect in NMIBC recurrence. The expression of TP53 and Ki67 could be used to predict the risk of NMIBC recurrence postoperatively.

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Year:  2013        PMID： 24241960     DOI： 10.1007/s13277-013-1384-9

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  32 in total

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Journal:  Am J Surg Pathol       Date:  1998-12       Impact factor: 6.394

2.  Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases.

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Journal:  Virchows Arch       Date:  2005-11-08       Impact factor: 4.064

Review 3.  P63 and P73: P53 mimics, menaces and more.

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Journal:  Nat Rev Mol Cell Biol       Date:  2000-12       Impact factor: 94.444

4.  Frequent alteration of p63 expression in human primary bladder carcinomas.

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Journal:  Cancer Res       Date:  2000-07-01       Impact factor: 12.701

5.  Radical cystectomy for bladder cancer today--a homogeneous series without neoadjuvant therapy.

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Journal:  J Clin Oncol       Date:  2003-02-15       Impact factor: 44.544

6.  Evaluation of P53 protein overexpression, Ki67 proliferative activity and mitotic index as markers of tumour recurrence in superficial transitional cell carcinoma of the bladder.

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Journal:  Eur Urol       Date:  2000-09       Impact factor: 20.096

Review 7.  Multivariate analysis of the prognostic factors of primary superficial bladder cancer.

Authors:  F Millán-Rodríguez; G Chéchile-Toniolo; J Salvador-Bayarri; J Palou; J Vicente-Rodríguez
Journal:  J Urol       Date:  2000-01       Impact factor: 7.450

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Authors:  Raj S Pruthi; Nathan Baldwin; Vishal Bhalani; Eric M Wallen
Journal:  J Urol       Date:  2007-11-12       Impact factor: 7.450

9.  Expression of cell-cycle regulatory proteins and their prognostic value in superficial low-grade urothelial cell carcinoma of the bladder.

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Journal:  Eur J Surg Oncol       Date:  2003-02       Impact factor: 4.424

10.  Predicting nonmuscle invasive bladder cancer recurrence and progression in patients treated with bacillus Calmette-Guerin: the CUETO scoring model.

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Journal:  J Urol       Date:  2009-09-16       Impact factor: 7.450
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  15 in total

1.  Prognostic value of Ki67 and p63 expressions in bladder cancer patients who underwent radical cystectomy.

Authors:  Lujia Wang; Minwei Zhou; Chenchen Feng; Peng Gao; Guanxiong Ding; Zhongwen Zhou; Haowen Jiang; Zhong Wu; Qiang Ding
Journal:  Int Urol Nephrol       Date:  2016-01-12       Impact factor: 2.370

2.  Ki-67 and Cell Cycle Regulators p53, p63 and cyclinD1 as Prognostic Markers for Recurrence/ Progression of Bladder Urothelial Carcinoma.

Authors:  Saba El-Gendi; Ghada Abu-Sheasha
Journal:  Pathol Oncol Res       Date:  2017-05-09       Impact factor: 3.201

3.  Cell Cycle Markers in the Evaluation of Bladder Cancer.

Authors:  Jéssica Niederauer Leote da Silva; Alana Durayski Ranzi; Caroline Trainotti Carvalho; Tales Vicente Scheide; Yuri Thomé Machado Strey; Túlio Meyer Graziottin; Claudia Giuliano Bica
Journal:  Pathol Oncol Res       Date:  2018-03-09       Impact factor: 3.201

4.  A study of the immunohistochemical profile of bladder cancer in neuro-urological patients by the French Association of Urology.

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Journal:  World J Urol       Date:  2022-02-09       Impact factor: 3.661

5.  CXCL5 is a potential diagnostic and prognostic marker for bladder cancer patients.

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Journal:  Tumour Biol       Date:  2015-10-27

6.  ESR1, ERBB2, and Ki67 mRNA expression predicts stage and grade of non-muscle-invasive bladder carcinoma (NMIBC).

Authors:  Johannes Breyer; Ralph M Wirtz; Mark Laible; Kornelia Schlombs; Philipp Erben; Maximilian Christian Kriegmair; Robert Stoehr; Sebastian Eidt; Stefan Denzinger; Maximilian Burger; Arndt Hartmann; Wolfgang Otto
Journal:  Virchows Arch       Date:  2016-08-11       Impact factor: 4.064

7.  Predictive value of clinicopathological markers for the metachronous bladder cancer and prognosis of upper tract urothelial carcinoma.

Authors:  Chenchen Feng; Lujia Wang; Guanxiong Ding; Qiang Ding; Zhongwen Zhou; Haowen Jiang; Zhong Wu
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8.  Copy number analysis of 24 oncogenes: MDM4 identified as a putative marker for low recurrence risk in non muscle invasive bladder cancer.

Authors:  Samanta Salvi; Daniele Calistri; Giorgia Gurioli; Elisa Carretta; Luigi Serra; Roberta Gunelli; Wainer Zoli; Valentina Casadio
Journal:  Int J Mol Sci       Date:  2014-07-14       Impact factor: 5.923

Review 9.  High Ki-67 Immunohistochemical Reactivity Correlates With Poor Prognosis in Bladder Carcinoma: A Comprehensive Meta-Analysis with 13,053 Patients Involved.

Authors:  Yihuan Luo; Xin Zhang; Meile Mo; Zhong Tan; Lanshan Huang; Hong Zhou; Chunqin Wang; Fanglin Wei; Xiaohui Qiu; Rongquan He; Gang Chen
Journal:  Medicine (Baltimore)       Date:  2016-04       Impact factor: 1.889

Review 10.  Frontiers in Bladder Cancer Genomic Research.

Authors:  Yi Li; Lihui Sun; Xiangyang Guo; Na Mo; Jinku Zhang; Chong Li
Journal:  Front Oncol       Date:  2021-05-20       Impact factor: 6.244
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