Literature DB >> 2424172

Vaccinia-mediated rescue of encephalomyocarditis virus from the inhibitory effects of interferon.

P Whitaker-Dowling, J S Youngner.   

Abstract

Coinfection of mouse L cells with vaccinia virus rescues encephalomyocarditis virus (EMC) from the inhibitory effect of interferon (IFN). The vaccinia-mediated rescue of EMC growth increases the yield of EMC as much as 1000-fold and is optimum when vaccinia is used at a multiplicity of infection of 1. This rescue correlates with a vaccinia-dependent stimulation of EMC gene expression. Evidence is presented to indicate that the rescue by vaccinia does not involve a block of the 2'-5'A synthetase pathway. However, the vaccinia rescue function is correlated with a vaccinia-mediated inhibition of the IFN-induced protein kinase.

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Year:  1986        PMID： 2424172     DOI： 10.1016/0042-6822(86)90370-3

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  9 in total

1.  Effect of interferon on Vero cells persistently infected with Sendai virus compared to Vero cells persistently infected with SSPE virus.

Authors:  M Crespi; M N Chiu; J K Struthers; B D Schoub; S F Lyons
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

2.  Inhibition of interferons by ectromelia virus.

Authors:  Vincent P Smith; Antonio Alcami
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

3.  Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.

Authors:  Ying Xiang; Richard C Condit; Sangeetha Vijaysri; Bertram Jacobs; Bryan R G Williams; Robert H Silverman
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

4.  The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.

Authors:  H W Chang; J C Watson; B L Jacobs
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

5.  The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

Authors:  M V Davies; O Elroy-Stein; R Jagus; B Moss; R J Kaufman
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

6.  Rescue of vaccinia virus lacking the E3L gene by mutants of E3L.

Authors:  H W Chang; L H Uribe; B L Jacobs
Journal:  J Virol       Date:  1995-10       Impact factor: 5.103

7.  Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.

Authors:  E Beattie; K L Denzler; J Tartaglia; M E Perkus; E Paoletti; B L Jacobs
Journal:  J Virol       Date:  1995-01       Impact factor: 5.103

Review 8.  Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response.

Authors:  Mateusz Szczerba; Sambhavi Subramanian; Kelly Trainor; Megan McCaughan; Karen V Kibler; Bertram L Jacobs
Journal:  Biomedicines       Date:  2022-01-22

Review 9.  Antagonism of Protein Kinase R by Large DNA Viruses.

Authors:  Annabel T Olson; Stephanie J Child; Adam P Geballe
Journal:  Pathogens       Date:  2022-07-12
  9 in total

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