Walter P Maksymowych1, Jolanda Cibere, Damien Loeuille, Ulrich Weber, Veronika Zubler, Frank W Roemer, Jacob L Jaremko, Eric C Sayre, Robert G W Lambert. 1. From the Department of Medicine, and the Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medicine, CHU de NANCY-Brabois, Vandoeuvre, France; Department of Rheumatology, Balgrist University Hospital, Zurich, Switzerland; Department of Radiology at University of Erlangen-Nuremberg, Klinikum Augsburg, Augsburg, Germany; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Arthritis Research Centre, Richmond, British Columbia, Canada.
Abstract
OBJECTIVE: Development of a validated magnetic resonance image (MRI) scoring system is essential in hip OA because radiographs are insensitive to change. We assessed the feasibility and reliability of 2 previously developed scoring methods: (1) the Hip Inflammation MRI Scoring System (HIMRISS) and (2) the Hip Osteoarthritis MRI Scoring System (HOAMS). METHODS: Six readers (3 radiologists, 3 rheumatologists) participated in 2 reading exercises. In Reading Exercise 1, MRI of the hip of 20 subjects were read at a single time point followed by further standardization of methodology. In Reading Exercise 2, MRI of the hip of 18 subjects from a randomized controlled trial, assessed at 2 timepoints, and 27 subjects from a cross-sectional study were read for HIMRISS and HOAMS bone marrow lesions (BML) and synovitis. Reliability was assessed using intraclass correlation coefficient (ICC) and kappa statistics. RESULTS: Both methods were considered feasible. For Reading 1, HIMRISS ICC were 0.52, 0.61, 0.70, and 0.58 for femoral BML, acetabular BML, effusion, and total scores, respectively; and for HOAMS, summed BML and synovitis ICC were 0.52 and 0.46, respectively. For Reading 2, HIMRISS and HOAMS ICC for BML and synovitis-effusion improved substantially. Interobserver reliability for change scores was 0.81 and 0.71 for HIMRISS femoral and HOAMS summed BML, respectively. Responsiveness and discrimination was moderate to high for synovitis-effusion. Significant associations were noted between BML or synovitis scores and Western Ontario and McMaster Universities Osteoarthritis Index pain scores for baseline values (p ≤ 0.001). CONCLUSION: The BML and synovitis-effusion components of both HIMRISS and HOAMS scoring systems are feasible and reliable, and should be validated further.
RCT Entities:
OBJECTIVE: Development of a validated magnetic resonance image (MRI) scoring system is essential in hip OA because radiographs are insensitive to change. We assessed the feasibility and reliability of 2 previously developed scoring methods: (1) the Hip Inflammation MRI Scoring System (HIMRISS) and (2) the Hip Osteoarthritis MRI Scoring System (HOAMS). METHODS: Six readers (3 radiologists, 3 rheumatologists) participated in 2 reading exercises. In Reading Exercise 1, MRI of the hip of 20 subjects were read at a single time point followed by further standardization of methodology. In Reading Exercise 2, MRI of the hip of 18 subjects from a randomized controlled trial, assessed at 2 timepoints, and 27 subjects from a cross-sectional study were read for HIMRISS and HOAMS bone marrow lesions (BML) and synovitis. Reliability was assessed using intraclass correlation coefficient (ICC) and kappa statistics. RESULTS: Both methods were considered feasible. For Reading 1, HIMRISS ICC were 0.52, 0.61, 0.70, and 0.58 for femoral BML, acetabular BML, effusion, and total scores, respectively; and for HOAMS, summed BML and synovitis ICC were 0.52 and 0.46, respectively. For Reading 2, HIMRISS and HOAMS ICC for BML and synovitis-effusion improved substantially. Interobserver reliability for change scores was 0.81 and 0.71 for HIMRISS femoral and HOAMS summed BML, respectively. Responsiveness and discrimination was moderate to high for synovitis-effusion. Significant associations were noted between BML or synovitis scores and Western Ontario and McMaster Universities Osteoarthritis Index pain scores for baseline values (p ≤ 0.001). CONCLUSION: The BML and synovitis-effusion components of both HIMRISS and HOAMS scoring systems are feasible and reliable, and should be validated further.
Entities:
Keywords:
MAGNETIC RESONANCE IMAGING; OMERACT; OSTEOARTHRITIS; SCORING METHOD; VALIDATION
Authors: G E Gold; F Cicuttini; M D Crema; F Eckstein; A Guermazi; R Kijowski; T M Link; E Maheu; J Martel-Pelletier; C G Miller; J-P Pelletier; C G Peterfy; H G Potter; F W Roemer; D J Hunter Journal: Osteoarthritis Cartilage Date: 2015-05 Impact factor: 6.576
Authors: Laura Tanturri de Horatio; Susan C Shelmerdine; Paola d'Angelo; Pier Luigi Di Paolo; Silvia Magni-Manzoni; Clara Malattia; Maria Beatrice Damasio; Paolo Tomà; Derk Avenarius; Karen Rosendahl Journal: Pediatr Radiol Date: 2022-09-23
Authors: Jacob L Jaremko; Dean Jeffery; M Buller; Stephanie Wichuk; Dave McDougall; Robert Gw Lambert; Walter P Maksymowych Journal: RMD Open Date: 2017-01-18
Authors: Andrew J Barr; T Mark Campbell; Devan Hopkinson; Sarah R Kingsbury; Mike A Bowes; Philip G Conaghan Journal: Arthritis Res Ther Date: 2015-08-25 Impact factor: 5.156