Anna Moniuszko1, Piotr Czupryna2, Sławomir Pancewicz2, Krzysztof Rutkowski3, Olga Zajkowska4, Renata Swierzbińska2, Sambor Grygorczuk2, Maciej Kondrusik2, Piotr Owłasiuk5, Joanna Zajkowska2. 1. Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Żurawia 14, 15-540 Bialystok, Poland. Electronic address: annamoniuszko@op.pl. 2. Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Żurawia 14, 15-540 Bialystok, Poland. 3. Department of Allergy, Cambridge University Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom. 4. Warsaw University of Life Sciences, Faculty of Applied Informatics and Mathematics, Nowourynowska 159, Warsaw 02-776, Poland. 5. Department of Observation and Infectious Diseases (with a Subdivision of Pediatric Observation and Infectious Diseases), District General Hospital, Piłsudskiego 11, 18-400 Łomża, Poland.
Abstract
PURPOSE: Knowledge of the role of chemokines in the inflammation during neuroborreliosis (NB) is limited. We evaluated the pre- and post-treatment concentration of CXCL8, CXCL10, CXCL11, CXCL12, and CXCL13 in serum (s) and cerebrospinal fluid (csf) in patients with NB. RESULTS: There was a statistically significant increase in pre-treatment s CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 and csf CXCL8, CXCL11, CXCL12, CXCL13 in patients with early form of NB. CXCL8, CXCL11, CXCL12 and CXCL13 increase was the highest in csf. After treatment, a significant decrease in csf chemokine levels (except CXCL10) and s levels (except CXCL11) was observed. CONCLUSIONS: CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 are involved in the pathomechanism of NB but their role is different in s and csf. CXCL13 seems to be a good biomarker for NB. In early NB, it may facilitate the diagnosis and monitoring of therapy. However tick-borne encephalitis needs to be excluded as it also increases chemokine concentration. Decrease in all examined chemokines in s and csf after treatment suggests that chemokines may be useful in monitoring response to NB therapy.
PURPOSE: Knowledge of the role of chemokines in the inflammation during neuroborreliosis (NB) is limited. We evaluated the pre- and post-treatment concentration of CXCL8, CXCL10, CXCL11, CXCL12, and CXCL13 in serum (s) and cerebrospinal fluid (csf) in patients with NB. RESULTS: There was a statistically significant increase in pre-treatment s CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 and csf CXCL8, CXCL11, CXCL12, CXCL13 in patients with early form of NB. CXCL8, CXCL11, CXCL12 and CXCL13 increase was the highest in csf. After treatment, a significant decrease in csf chemokine levels (except CXCL10) and s levels (except CXCL11) was observed. CONCLUSIONS:CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 are involved in the pathomechanism of NB but their role is different in s and csf. CXCL13 seems to be a good biomarker for NB. In early NB, it may facilitate the diagnosis and monitoring of therapy. However tick-borne encephalitis needs to be excluded as it also increases chemokine concentration. Decrease in all examined chemokines in s and csf after treatment suggests that chemokines may be useful in monitoring response to NB therapy.
Authors: Jerome Bouquet; Mark J Soloski; Andrea Swei; Chris Cheadle; Scot Federman; Jean-Noel Billaud; Alison W Rebman; Beniwende Kabre; Richard Halpert; Meher Boorgula; John N Aucott; Charles Y Chiu Journal: MBio Date: 2016-02-12 Impact factor: 7.867