| Literature DB >> 24239756 |
Heather A Hong1, Maria Paximadis, Glenda E Gray, Louise Kuhn, Caroline T Tiemessen.
Abstract
KIR2DS4 is the only activating gene within the A haplotype, and alleles of KIR2DS4 can encode either functional (KIR2DS4-f) or non-functional (KIR2DS4-v) variants. To establish the role of KIR2DS4 in the context of HIV-1 mother-to-child transmission, we KIR genotyped 145 HIV-1 non-transmitting mothers (NT) and their exposed uninfected infants (EU), and 72 HIV-1 transmitting mothers (TR) and their infected infants [intrapartum (IP), in utero (IU) or IU2 (an IU-enriched infected group)]. The frequency of KIR2DS4-v was significantly higher in IU2 infants compared to EU infants (P=0.022, OR=2.88); this association was more significant amongst AA haplotypes (P=0.004, OR=18.4). Possession of KIR2DS4-f in the mother with absence in the infant (M+I- discordance) was associated with a higher risk of IP transmission (P=0.005, OR=3.84); whilst in M-I+ discordance, infant possession of KIR2DS4-v was associated with increased risk of IU acquisition (P=0.002; OR=6.40). This study highlights the importance of KIR2DS4 in HIV-1 transmission/acquisition.Entities:
Keywords: HLA-C ligands;; Killer cell immunoglobulin-like receptors (KIRs);; Mother-to-child-transmission (MTCT); NK function;; Natural killer (NK) cells;
Mesh：
Substances：
Year: 2013 PMID： 24239756 DOI： 10.1016/j.clim.2013.09.005
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969